Modified constraint-induced movement therapy enhances cortical plasticity in a rat model of traumatic brain injury: a resting-state functional MRI study
机构：[1]Department of Rehabilitation, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China[2]Institute of Science and Technology for Brain-Inspired Intelligence, FudanUniversity, Shanghai, China[3]Center of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, China[4]Institute of RehabilitationMedicine, School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China[5]Engineering Research Center of Traditional Chinese MedicineIntelligent Rehabilitation, Ministry of Education, Shanghai, China[6]Department of Rehabilitation, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China[7]Department of Rehabilitation, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[8]Department of Rehabilitation, Shanghai Jiao Tong UniversityAffiliated Sixth People’s Hospital, Shanghai, China[9]Department of Traumatology and Orthopedics, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai,China[10]Department of Rehabilitation, Yangzhi Rehabilitation Hospital, Tongji University, Shanghai, China[11]Human Phenome Institute, Fudan University, Shanghai, China[12]KeyLaboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China
Modified constraint-induced movement therapy (mCIMT) has shown beneficial effects on motor function improvement after brain injury, but the exact mechanism remains unclear. In this study, amplitude of low frequency fluctuation (ALFF) metrics measured by resting-state functional magnetic resonance imaging was obtained to investigate the efficacy and mechanism of mCIMT in a control cortical impact (CCI) rat model simulating traumatic brain injury. At 3 days after control cortical impact model establishment, we found that the mean ALFF (mALFF) signals were decreased in the left motor cortex, somatosensory cortex, insula cortex and the right motor cortex, and were increased in the right corpus callosum. After 3 weeks of an 8-hour daily mCIMT treatment, the mALFF values were significantly increased in the bilateral hemispheres compared with those at 3 days postoperatively. The mALFF signal values of left corpus callosum, left somatosensory cortex, right medial prefrontal cortex, right motor cortex, left postero dorsal hippocampus, left motor cortex, right corpus callosum, and right somatosensory cortex were increased in the mCIMT group compared with the control cortical impact group. Finally, we identified brain regions with significantly decreased mALFF values at 3 days postoperatively. Pearson correlation coefficients with the right forelimb sliding score indicated that the improvement in motor function of the affected upper limb was associated with an increase in mALFF values in these brain regions. Our findings suggest that functional cortical plasticity changes after brain injury, and that mCIMT is an effective method to improve affected upper limb motor function by promoting bilateral hemispheric cortical remodeling. mALFF values correlate with behavioral changes and can potentially be used as biomarkers to assess dynamic cortical plasticity after traumatic brain injury.
基金：
National Key R&D Program of China, Nos. 2020YFC2004202 (to DSX), 2018YFC2001600 (to XYH); the National Natural Science Foundation of China, Nos. 81974358 (to DSX), 81802249 (to XYH) and 82172554 (to XYH).
第一作者机构：[1]Department of Rehabilitation, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
共同第一作者：
通讯作者：
通讯机构：[2]Institute of Science and Technology for Brain-Inspired Intelligence, FudanUniversity, Shanghai, China[3]Center of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, China[4]Institute of RehabilitationMedicine, School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China[5]Engineering Research Center of Traditional Chinese MedicineIntelligent Rehabilitation, Ministry of Education, Shanghai, China[9]Department of Traumatology and Orthopedics, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai,China[10]Department of Rehabilitation, Yangzhi Rehabilitation Hospital, Tongji University, Shanghai, China[11]Human Phenome Institute, Fudan University, Shanghai, China[12]KeyLaboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China
推荐引用方式(GB/T 7714)：
Cheng-Cheng Sun,Yu-Wen Zhang,Xiang-Xin Xing,et al.Modified constraint-induced movement therapy enhances cortical plasticity in a rat model of traumatic brain injury: a resting-state functional MRI study[J].NEURAL REGENERATION RESEARCH.2023,18(2):410-415.doi:10.4103/1673-5374.344832.
APA：
Cheng-Cheng Sun,Yu-Wen Zhang,Xiang-Xin Xing,Qi Yang,Ling-Yun Cao...&Dong-Sheng Xu.(2023).Modified constraint-induced movement therapy enhances cortical plasticity in a rat model of traumatic brain injury: a resting-state functional MRI study.NEURAL REGENERATION RESEARCH,18,(2)
MLA：
Cheng-Cheng Sun,et al."Modified constraint-induced movement therapy enhances cortical plasticity in a rat model of traumatic brain injury: a resting-state functional MRI study".NEURAL REGENERATION RESEARCH 18..2(2023):410-415
