Background Multiple tools have been applied to radiomics evaluation, while evidence rating tools for this field are still lacking. This study aims to assess the quality of pancreatitis radiomics research and test the feasibility of the evidence level rating tool. Results Thirty studies were included after a systematic search of pancreatitis radiomics studies until February 28, 2022, via five databases. Twenty-four studies employed radiomics for diagnostic purposes. The mean +/- standard deviation of the adherence rate was 38.3 +/- 13.3%, 61.3 +/- 11.9%, and 37.1 +/- 27.2% for the Radiomics Quality Score (RQS), the Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD) checklist, and the Image Biomarker Standardization Initiative (IBSI) guideline for preprocessing steps, respectively. The median (range) of RQS was 7.0 (- 3.0 to 18.0). The risk of bias and application concerns were mainly related to the index test according to the modified Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. The meta-analysis on differential diagnosis of autoimmune pancreatitis versus pancreatic cancer by CT and mass-forming pancreatitis versus pancreatic cancer by MRI showed diagnostic odds ratios (95% confidence intervals) of, respectively, 189.63 (79.65-451.48) and 135.70 (36.17-509.13), both rated as weak evidence mainly due to the insufficient sample size. Conclusions More research on prognosis of acute pancreatitis is encouraged. The current pancreatitis radiomics studies have insufficient quality and share common scientific disadvantages. The evidence level rating is feasible and necessary for bringing the field of radiomics from preclinical research area to clinical stage.
基金：
National Natural Science Foundation of China [81771789, 81771790]; Yangfan Project of Science and Technology Commission of Shanghai Municipality [22YF1442400]; Shanghai Science and Technology Commission Science and Technology Innovation Action Clinical Innovation Field [18411953000]; Medicine and Engineering Combination Project of Shanghai Jiao Tong University [YG2019ZDB09]; Research Fund of Tongren Hospital, Shanghai Jiao Tong University School of Medicine [TRKYRCXX202204, 2020TRYJ(LB)06, 2020TRYJ(JC)07, TRGG202101, TRYJ2021JC06]
第一作者机构：[1]Shanghai Jiao Tong Univ, Tongren Hosp, Dept Imaging, Sch Med, 1111 Xianxia Rd, Shanghai 200336, Peoples R China
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推荐引用方式(GB/T 7714)：
Zhong Jingyu,Hu Yangfan,Xing Yue,et al.A systematic review of radiomics in pancreatitis: applying the evidence level rating tool for promoting clinical transferability[J].INSIGHTS INTO IMAGING.2022,13(1):doi:10.1186/s13244-022-01279-4.
APA：
Zhong, Jingyu,Hu, Yangfan,Xing, Yue,Ge, Xiang,Ding, Defang...&Yao, Weiwu.(2022).A systematic review of radiomics in pancreatitis: applying the evidence level rating tool for promoting clinical transferability.INSIGHTS INTO IMAGING,13,(1)
MLA：
Zhong, Jingyu,et al."A systematic review of radiomics in pancreatitis: applying the evidence level rating tool for promoting clinical transferability".INSIGHTS INTO IMAGING 13..1(2022)
