Coronavirus Disease 2019 (COVID-19) is currently a global pandemic, and early screening is one of the key factors for COVID-19 control and treatment. Here, we developed and validated chest CT-based imaging biomarkers for COVID-19 patient screening from two independent hospitals with 419 patients. We identified the vasculature-like signals from CT images and found that, compared to healthy and community acquired pneumonia (CAP) patients, COVID-19 patients display a significantly higher abundance of these signals. Furthermore, unsupervised feature learning led to the discovery of clinical-relevant imaging biomarkers from the vasculature-like signals for accurate and sensitive COVID-19 screening that have been double-blindly validated in an independent hospital (sensitivity: 0.941, specificity: 0.920, AUC: 0.971, accuracy 0.931, F1 score: 0.929). Our findings could open a new avenue to assist screening of COVID-19 patients.
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|3 区医学
小类|3 区公共卫生、环境卫生与职业卫生
最新[2025]版：
大类|3 区医学
小类|3 区公共卫生、环境卫生与职业卫生
JCR分区：
出版当年[2020]版：
Q1PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTHQ2PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
第一作者机构：[1]Wuhan Univ, Dept Pathol, Zhongnan Hosp, Wuhan, Peoples R China[2]Wuhan Univ, Dept Urol, Zhongnan Hosp, Wuhan, Peoples R China
共同第一作者：
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推荐引用方式(GB/T 7714)：
Liu Xiao-Ping,Yang Xu,Xiong Miao,et al.Development and validation of chest CT-based imaging biomarkers for early stage COVID-19 screening[J].FRONTIERS IN PUBLIC HEALTH.2022,10:doi:10.3389/fpubh.2022.1004117.
APA：
Liu, Xiao-Ping,Yang, Xu,Xiong, Miao,Mao, Xuanyu,Jin, Xiaoqing...&Chang, Hang.(2022).Development and validation of chest CT-based imaging biomarkers for early stage COVID-19 screening.FRONTIERS IN PUBLIC HEALTH,10,
MLA：
Liu, Xiao-Ping,et al."Development and validation of chest CT-based imaging biomarkers for early stage COVID-19 screening".FRONTIERS IN PUBLIC HEALTH 10.(2022)
