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Metabolic crosstalk between thermogenic adipocyte and cancer cell: Dysfunction and therapeutics

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收录情况： ◇ SCIE

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机构： [1]Department of Urology, Changhai Hospital, Naval Medical University, Shanghai 200433, China. [2]Beijing Diabetes Institute, Beijing Key Laboratory of Diabetes Research and Care, Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. [3]Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China. [4]Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.

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关键词： Metabolism Thermogenic adipocyte Tumour microenvironment

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As one of the largest endocrine organs with a wide distribution in organisms, adipose tissue secretes multiple adipokines, cytokines, metabolites, and exosomes to promote tumour development. Elaborating the crosstalk between cancer cells and adipocytes provides a tissue-level perspective of cancer progression, which reflects the heterogeneity and complexity of human tumours. Three main types of adipose tissues, white, brown, and beige adipose tissue, have been described. Thermogenic capacity is a prominent characteristic of brown and beige adipocytes. Most studies so far mainly focus on the contribution of white adipocytes to the tumour microenvironment. However, the role of thermogenic adipose tissue in malignant cancer behaviour has been largely overlooked. Recently, emerging evidence suggests that beige/brown adipocytes play a key role in the development and progression of various cancers. This review focuses on the bidirectional communication between tumour cells and thermogenic adipocytes and the therapeutic strategies to disrupt this interaction.Copyright © 2022 Elsevier Ltd. All rights reserved.

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出版当年[2022]版中科院分区表Review为是的期刊

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大类 | 3 区医学

小类 | 3 区药学

最新[2023]版

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大类 | 3 区医学

小类 | 3 区药学

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出版当年[2021]版：

Q2 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q1 PHARMACOLOGY & PHARMACY

影响因子： 4 最新[2023版] 4.1 最新五年平均 4.768 出版当年[2021版] 5.605 出版当年五年平均 5.547 出版前一年[2020版] 4 出版后一年[2022版]

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第一作者机构： [1]Department of Urology, Changhai Hospital, Naval Medical University, Shanghai 200433, China.

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