机构：[1]Cardiovascular Center, 117902Beijing Tongren Hospital, Capital Medical University, Beijing, China.首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]248912Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.[3]Department of Ultrasound, 26455Beijing Friendship Hospital, Capital Medical University, Beijing, China.首都医科大学附属北京友谊医院[4]Trauma Medicine Center, 71185Peking University People's Hospital, Beijing, China.[5]Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, UK.[6]Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.[7]Department of Cardiac Surgery, 12667Beijing Anzhen Hospital, Capital Medical University, Beijing, China.首都医科大学附属安贞医院
Left atrial thrombus (LAT) often complicates with atrial fibrillation (AF). The evidence whether fibrin D-dimer levels could be used as a predictive biomarker for LAT is contradictory. This study firstly investigated the relationship between 'normal range' D-dimer and prevalent LAT. Second, we explored factors contributing to normal D-dimer levels in the presence of LAT.We studied 244 AF patients with LAT (mean age: 59.9 years, SD:11.7; 53.3% female): of these, 103 (42.2%) had normal D-dimer, 25 (10.2%) had atrial thrombus exclusion score (ATE score) of 0 19 (16.7%) males had CHA2DS2-VASc score of 0, 21(16.2%) females had CHA2DS2-VASc score of 1 and 16 had overlapped ATE score of 0 and CHA2DS2-VASc score of 0 (N = 8 if male) or CHA2DS2-VASc score of 1(N = 8 if female). Using multivariate binary analysis, larger left atrial diameter (LAD; adjusted OR: 1.06, 1.03-1.10, p = 0.001) were associated with increased D-dimer. Patients with high body mass index (BMI), hypertension history and previous anticoagulation were more likely to show normal range D-dimer levels in the presence of LAT.A high prevalence (42.2%) of 'normal range' D-dimer levels was found in AF patients with LAT, especially in those with hypertension, high BMI and prior anticoagulation. D-dimer levels of those patients with larger LAD were more likely to be increased.
基金：
National Natural Science
Foundation of China (81800291)
第一作者机构：[1]Cardiovascular Center, 117902Beijing Tongren Hospital, Capital Medical University, Beijing, China.
通讯作者：
通讯机构：[2]248912Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.[7]Department of Cardiac Surgery, 12667Beijing Anzhen Hospital, Capital Medical University, Beijing, China.[*1]Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China[*2]Dongzhimen Hospital, Beijing University of Chinese Medicine, 101121, China.
推荐引用方式(GB/T 7714)：
Bai Ying,Luo Si-Qing,Liu Si-Tong,et al.Clinical Features Associated with 'Normal Range' Fibrin D-Dimer Levels in Atrial Fibrillation Patients with Left Atrial Thrombus[J].CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS.2022,28:doi:10.1177/10760296221133380.
APA：
Bai Ying,Luo Si-Qing,Liu Si-Tong,Gong Ling,Zhong Peng...&Guo Wei-Hua.(2022).Clinical Features Associated with 'Normal Range' Fibrin D-Dimer Levels in Atrial Fibrillation Patients with Left Atrial Thrombus.CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS,28,
MLA：
Bai Ying,et al."Clinical Features Associated with 'Normal Range' Fibrin D-Dimer Levels in Atrial Fibrillation Patients with Left Atrial Thrombus".CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS 28.(2022)
