机构：[1]Department of Cardiology, Beijing Chao-Yang Hospital, Capital Medical University.北京朝阳医院[2]Department of Internal Medicine, Jinzhou Center for Disease Control and Prevention.[3]Department of Cardiology, Peking University Shougang Hospital.[4]Department of Cardiology, Beijing Tongren Hospital, Capital Medical University.临床科室心血管中心首都医科大学附属北京同仁医院首都医科大学附属同仁医院
Atrial fibrillation (AF) is a common arrhythmia in clinical. Its most important pathophysiological factor is atrial fibrosis. Transferrin receptor (TFRC) promotes ferroptosis by facilitating iron uptake. Its role in AF is unknown. TFRC expression in Angiotensin II (Ang II)-induced AF mice was significantly upregulated. TFRC knockdown significantly reduced AF occurrence. TFRC silence ameliorated myocardial fibrosis by inhibiting TGF-β1/Smad2 pathway in vivo. TFRC interference reduced ferroptosis by inhibiting lipid oxidation product generation in vivo. Ang II-induced HL-1 cardiomyocyte model was employed to simulate an in vivo situation. The in vitro results were consistent with the in vivo results. FOXO3 was reported to protect atrium against fibrosis and participate in ferroptosis. FOXO3 exerted transcriptional repressive activity by binding to TFRC promoter. FOXO3 overexpression protected HL-1 cells against ferroptosis, which was reversed by TFRC overexpression. In summary, TFRC knockdown reduces AF occurrence by ameliorating atrial fibrosis through inhibiting cardiomyocyte ferroptosis under FOXO3 regulation.
基金：
This research was funded by the National Natural Science Foundation of China (No. 82270325, Xingpeng Liu).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类|3 区农林科学
小类|3 区兽医学3 区动物学
最新[2025]版：
大类|3 区农林科学
小类|3 区兽医学3 区动物学
第一作者：
第一作者机构：[1]Department of Cardiology, Beijing Chao-Yang Hospital, Capital Medical University.
通讯作者：
推荐引用方式(GB/T 7714)：
Zhan Yufei,Zhou Yang,Zhang Chi,et al.TFRC knockdown attenuates atrial fibrillation by inhibiting cardiomyocyte ferroptosis and atrial fibrosis[J].Experimental Animals.2025,doi:10.1538/expanim.24-0127.
APA：
Zhan Yufei,Zhou Yang,Zhang Chi,Zhai Zongwang,Yang Yi&Liu Xingpeng.(2025).TFRC knockdown attenuates atrial fibrillation by inhibiting cardiomyocyte ferroptosis and atrial fibrosis.Experimental Animals,,
MLA：
Zhan Yufei,et al."TFRC knockdown attenuates atrial fibrillation by inhibiting cardiomyocyte ferroptosis and atrial fibrosis".Experimental Animals .(2025)
