PurposeTo examine whether corneal epithelial dendritic cells (CEDC) could serve as an indicator to distinguish obstructive meibomian gland dysfunction (MGD) with or without ocular surface inflammation (OSI).MethodsWe performed a case-control study on patients with diagnosed obstructive MGD between August 2017 and November 2019.Results30 MGD cases and 25 healthy controls were recruited. The classification of MGD patients with and without OSI was based on the tear pro-inflammatory cytokine levels. Compared with the MGD without OSI and the control group, a higher CEDC density was detected in the MGD with OSI subgroup. The presence of >15.6 cells/mm(2) CEDC had a sensitivity of 73% and specificity of 75% for the diagnosis of MGD with OSI.ConclusionsOSI is not present in all patients with obstructive MGD. Evaluation of CEDC density in the central cornea may help identify whether MGD is concomitant with OSI.
基金：
This work was supported by the National Natural Science Foundation of
China [number 81970765].
第一作者机构：[1]Capital Med Univ, Beijing Inst Ophthalmol, Beijing Key Lab Ophthalmol & Visual Sci, Beijing Tongren Eye Ctr,Beijing Tongren Hosp, Beijing 100005, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Inst Ophthalmol, Beijing Key Lab Ophthalmol & Visual Sci, Beijing Tongren Eye Ctr,Beijing Tongren Hosp, Beijing 100005, Peoples R China[*1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100005, China
推荐引用方式(GB/T 7714)：
Chen Qiankun,Wang Leying,Zhang Yuheng,et al.Corneal Epithelial Dendritic Cells: An Objective Indicator for Ocular Surface Inflammation in Patients with Obstructive Meibomian Gland Dysfunction?[J].OCULAR IMMUNOLOGY AND INFLAMMATION.2024,32(1):79-88.doi:10.1080/09273948.2022.2155843.
APA：
Chen, Qiankun,Wang, Leying,Zhang, Yuheng,Xu, Xizhan,Wei, Zhenyu...&Liang, Qingfeng.(2024).Corneal Epithelial Dendritic Cells: An Objective Indicator for Ocular Surface Inflammation in Patients with Obstructive Meibomian Gland Dysfunction?.OCULAR IMMUNOLOGY AND INFLAMMATION,32,(1)
MLA：
Chen, Qiankun,et al."Corneal Epithelial Dendritic Cells: An Objective Indicator for Ocular Surface Inflammation in Patients with Obstructive Meibomian Gland Dysfunction?".OCULAR IMMUNOLOGY AND INFLAMMATION 32..1(2024):79-88
