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Mechanical protective effect of lens anterior capsule disc on corneal endothelial cells during femtosecond laser-assisted cataract surgery in a rabbit model

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机构： [1]Aier School of Ophthalmology, Central South University, No.932, Lushan South Road, Changsha, Hunan province, China [2]Beijing Aier-Intech Eye Hospital, Beijing, China [3]Institute of Corneatology in Aier Eye Hospital, Beijing, China [4]Tianjin University Aier Eye Hospital, Tianjin, China

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关键词： Isolated capsulotomy disc technique lens anterior capsule disc femtosecond laser-assisted cataract surgery Corneal endothelial cell Phacoemulsification Ophthalmic viscoelastic devices Endothelial cell loss

摘要：

To evaluate the effects of a novel technique using an isolated lens anterior capsule disc (LACD) to protect corneal endothelial cells in rabbit eyes during femtosecond laser-assisted cataract surgery.Experimental study. 40 rabbits were divided into endothelium-protected (experimental) and control groups, with 20 rabbits in each group. In the experimental group, after femtosecond laser capsulotomy, the isolated capsule disc was lifted to the corneal endothelium by an ophthalmic viscosurgical device. The endothelium was damaged for 1 min with an ultrasonic probe. The control group underwent the same surgery, except that the disc was removed immediately after capsulorhexis. Corneal endothelioscopy was performed preoperatively and on postoperative days (PODs) 3 and 7 to observe endothelial cell counts (ECC) and endothelial cell loss rate. Central corneal thickness (CCT) was measured before and at PODs 1, 3 and 7.There were 3.59%±1.88% (p < 0.001) and 2.92%±2.14% (p < 0.001) loss of ECC in experimental group at POD3 and POD7, respectively, while those in the control group were 11.62%±7.43% and 10.34%±5.77%, respectively. On POD 1, the difference in central corneal thickness was significant(P = 0.019) between the two groups. At POD 3 and POD 7, CCT was not significantly different (P = 0.597;0.913) between the two groups.The isolated LACD technique significantly reduced damage to the endothelium caused by ultrasonic energy and protects corneal endothelial cells during phacoemulsification.© 2023. The Author(s).

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出版当年[2022]版：

大类 | 4 区医学

小类 | 4 区眼科学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区眼科学

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第一作者机构： [1]Aier School of Ophthalmology, Central South University, No.932, Lushan South Road, Changsha, Hunan province, China

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通讯机构： [1]Aier School of Ophthalmology, Central South University, No.932, Lushan South Road, Changsha, Hunan province, China [2]Beijing Aier-Intech Eye Hospital, Beijing, China [3]Institute of Corneatology in Aier Eye Hospital, Beijing, China

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