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N6-methyladenosine methylation mediates non-coding RNAs modification in microplastic-induced cardiac injury

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收录情况： ◇ SCIE

作者：
Zhang Min[1] * ; Shi Jun[2] * ; Zhou Jun[1] * ; Song Lei[1] ; Ding Jingjing[3] ; Deng Hui Ping[2] ; Weng Li[4] ; Zhu Yiqian[5] ; Xu Zhongqing[3] ;
机构： [1]Division of Cardiology, Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 200336 Shanghai, China [2]Shanghai Institute of Pollution Control and Ecological Security, Key Laboratory of Yangtze River Water Environment Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai, China [3]Department of General Practice, Tongren Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China [4]Department of Intervention, Tongren Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China [5]Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China
出处：
DOI： 10.1016/j.ecoenv.2023.115174
ISSN：

关键词： Microplastics Cardiotoxicity N6-methyladenosine Circ-Arfgef2 LncG3bp2

摘要：
Owing to their potential adverse health effects, global contamination by microplastics (MPs) has attracted increased scientific and societal concerns. However, in vivo studies on MP toxicity, along with its effects and underlying mechanisms, remain limited. We recently found that non-coding RNA (ncRNAs) contribute to MP-mediated vascular toxicity. Moreover, previous studies have identified N6-methyladenosine (m6A) modifications in ncRNAs as influencing factors in cardiovascular disease. However, whether and how m6A modifications in ncRNAs are affected by MP-induced cardiotoxicity remain unknown. Herein, we profiled differentially expressed ncRNAs and their related m6A modification profiles in MP-exposed myocardial tissue using RNA sequencing (RNA-seq) and methylated RNA immunoprecipitation sequencing (MeRIP-seq). First, we observed that MPs accumulated in different organs and upregulated apoptosis in the heart, liver, spleen, and kidney cells. Furthermore, total m6A and METTL3 levels increased in the myocardium after exposure to MPs. RNA-seq results revealed that 392 lncRNAs and 302 circRNAs were differentially expressed in MP-treated mouse myocardium compared to the control group. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses showed that these altered lncRNAs and circRNAs were closely associated with endocytosis, cellular senescence, and cell cycle signaling pathways, which may cause cardiotoxicity. Furthermore, MeRIP-seq data showed different distributions and abundances of m6A modifications in lncRNAs and circRNAs. Additionally, we identified differentially m6A methylated lncRNAs and circRNAs through conjoint analysis of the two high-throughput sequencing datasets and found that both m6A modifications and the expression of circ-Arfgef2 and lncG3bp2 were upregulated after exposure to MPs. This suggests that MP-induced m6A modifications in ncRNAs are involved in cardiotoxicity. Our findings contribute to a better understanding of MP-induced cardiotoxicity and new molecular targets for treating cardiac injury.Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

基金：
This work was supported by the National Natural Science Foundation of China (No. 82270459 and 82001931).
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外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 环境科学与生态学
小类 | 1 区 毒理学 2 区 环境科学
最新[2025]版：
大类 | 2 区 环境科学与生态学
小类 | 1 区 毒理学 2 区 环境科学
JCR分区：
出版当年[2021]版：
Q1 ENVIRONMENTAL SCIENCES Q1 TOXICOLOGY
最新[2023]版：
Q1 ENVIRONMENTAL SCIENCES Q1 TOXICOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Division of Cardiology, Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 200336 Shanghai, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Min,Shi Jun,Zhou Jun,et al.N6-methyladenosine methylation mediates non-coding RNAs modification in microplastic-induced cardiac injury[J].ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY.2023,262:doi:10.1016/j.ecoenv.2023.115174.
APA：
Zhang Min,Shi Jun,Zhou Jun,Song Lei,Ding Jingjing...&Xu Zhongqing.(2023).N6-methyladenosine methylation mediates non-coding RNAs modification in microplastic-induced cardiac injury.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,262,
MLA：
Zhang Min,et al."N6-methyladenosine methylation mediates non-coding RNAs modification in microplastic-induced cardiac injury".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 262.(2023)

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