机构：[1]Beijing Ophthalmology & Visual Sciences Key Laboratory,Beijing Tongren Eye Center,Beijing Tongren Hospital,Beijing Institute of Ophthalmology,Capital Medical University,Beijing,China首都医科大学附属北京同仁医院临床科室眼科屈光手术中心斜视与小儿眼科研究所眼科研究所[2]Department of Clinical Medicine, Capital Medical University, Beijing, China
This research aimed to determine the effects of near work on macular choroidal blood flow and thickness in young adults.A total of 109 participants (19-28 years old) were recruited from Capital Medical University in China. The participants spent 40 min reading a book text at a distance of 33 cm. Swept-source optical coherence tomography/optical coherence tomography angiography (SS-OCT/OCTA) was performed to measure the changes in choriocapillaris perfusion area (CCPA) and choroidal thickness (ChT) after 40 min of near work. The SS-OCT/OCTA data covered an area of 6 mm × 6 mm, which centered on the fovea.The baseline ChT and CCPA before near work were negatively correlated with AL, while positively correlated with the magnitude of spherical equivalent (p < .001). Total CCPA decreased significantly by 6 mm × 6 mm macular area after near work compared to that before near work (24.26 ± 1.96 vs. 24.63 ± 1.61 mm2, p<.001). The macular ChT was lower after 40 min of reading than that before 40 min of reading, but no significant difference was observed (302.25 ± 77.69 vs. 304.92 ± 79.73 μm, p = .078). The extent of choroidal thinning was significantly positively correlated with the magnitude of CCPA reduction (p < .001). The decline in CCPA after near work was significantly positively correlated with axial length (AL; p < .001).This study demonstrated that near work significantly decreased CCPA. The extent of CCPA reduction after near work was associated with higher severity of myopia and choroidal thinning. The baseline CCPA and ChT decreased gradually with AL.
基金：
This work was supported by grants from the Beijing Municipal
Administration of Hospitals Incubating Program (PX2022007), the
primary scientific research foundation for the junior researcher in
Beijing Tongren Hospital, Capital Medical University (2020-YJJZZL-
011), the capital health research and development of special
(2020-2-1081), the National Natural Science Foundation of China
(82071000), and the Beijing Science Foundation for Distinguished
Young Scholars (JQ20029).
第一作者机构：[1]Beijing Ophthalmology & Visual Sciences Key Laboratory,Beijing Tongren Eye Center,Beijing Tongren Hospital,Beijing Institute of Ophthalmology,Capital Medical University,Beijing,China
通讯作者：
通讯机构：[1]Beijing Ophthalmology & Visual Sciences Key Laboratory,Beijing Tongren Eye Center,Beijing Tongren Hospital,Beijing Institute of Ophthalmology,Capital Medical University,Beijing,China[*1]Beijing Ophthalmology and Visual Science Key Laboratory,Beijing Tongren Eye Center,Beijing Tongren Hospital,Beijing Institute of Ophthalmology,Capital Medical University,No.1 Dongjiaominxiang Street,Dongcheng District,Beijing 100730,China
推荐引用方式(GB/T 7714)：
Liang Xintong,Wei Shifei,Zhao Shengjun,et al.Investigation of Choroidal Blood Flow and Thickness Changes Induced by Near Work in Young Adults[J].CURRENT EYE RESEARCH.2023,48(10):939-948.doi:10.1080/02713683.2023.2222234.
APA：
Liang Xintong,Wei Shifei,Zhao Shengjun,Li Shi-Ming,An Wenzai...&Wang Ningli.(2023).Investigation of Choroidal Blood Flow and Thickness Changes Induced by Near Work in Young Adults.CURRENT EYE RESEARCH,48,(10)
MLA：
Liang Xintong,et al."Investigation of Choroidal Blood Flow and Thickness Changes Induced by Near Work in Young Adults".CURRENT EYE RESEARCH 48..10(2023):939-948
