机构：[1]Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China临床科室耳鼻咽喉-头颈外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Beijing Key Laboratory of Nasal Diseases, Beijing Laboratory of Allergic Diseases, Beijing Institute of Otolaryngology, Beijing, China研究所耳鼻咽喉科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China临床科室变态反应科首都医科大学附属北京同仁医院首都医科大学附属同仁医院
Introduction: Epithelial-mesenchymal transition (EMT) is a type of epithelial cell dysfunction, which is widely present in the nasal mucosa of patients with chronic rhinosinusitis (CRS), especially CRS with nasal polyps, and contributes to pathogenesis of the disease. EMT is mediated via complex mechanisms associated with multiple signaling pathways.Areas covered: We have summarized the underlying mechanisms and signaling pathways promoting EMT in CRS. Strategies or drugs/agents targeting the genes and pathways related to the regulation of EMT are also discussed for their potential use in the treatment of CRS and asthma. A literature search of studies published in English from 2000 to 2023 was conducted using the PubMed database, employing CRS, EMT, signaling, mechanisms, targeting agents/drugs, as individual or combinations of search terms.Expert opinion: EMT in nasal epithelium not only leads to epithelial cell dysfunction but also plays an important role in nasal tissue remodeling in CRS. A comprehensive understanding of the mechanisms underlying EMT and the development of drugs/agents targeting these mechanisms may provide new treatment strategies for CRS.
基金：
national key Ramp;D program of China [2022YFC2504100]; national natural science foundation of China [82025010, 82171109]; program for the Changjiang scholars and innovative research team [IRT13082]; Beijing municipal administration of hospitals' Dengfeng/Youth plan [DFL20190202, QML20200202]; CAMS Innovation Fund for Medical Sciences [2019-I2M-5-022]
第一作者机构：[1]Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China[2]Beijing Key Laboratory of Nasal Diseases, Beijing Laboratory of Allergic Diseases, Beijing Institute of Otolaryngology, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China[2]Beijing Key Laboratory of Nasal Diseases, Beijing Laboratory of Allergic Diseases, Beijing Institute of Otolaryngology, Beijing, China[3]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China[*1]Department of Otolaryngology Head and Neck surgery and department of Allergy, Beijing TongRen Hospital, Capital Medical University, No.1, DongJiaoMinXiang, DongCheng District, Beijing 100730, China
推荐引用方式(GB/T 7714)：
Yuan Jing,Wang Ming,Wang Chengshuo,et al.Epithelial cell dysfunction in chronic rhinosinusitis: the epithelial-mesenchymal transition[J].EXPERT REVIEW OF CLINICAL IMMUNOLOGY.2023,19(8):959-968.doi:10.1080/1744666X.2023.2232113.
APA：
Yuan, Jing,Wang, Ming,Wang, Chengshuo&Zhang, Luo.(2023).Epithelial cell dysfunction in chronic rhinosinusitis: the epithelial-mesenchymal transition.EXPERT REVIEW OF CLINICAL IMMUNOLOGY,19,(8)
MLA：
Yuan, Jing,et al."Epithelial cell dysfunction in chronic rhinosinusitis: the epithelial-mesenchymal transition".EXPERT REVIEW OF CLINICAL IMMUNOLOGY 19..8(2023):959-968
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