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Sensitisation to House Dust Mite Component Der p 23 Is Associated with Severe Symptoms and Asthma in Allergic Rhinitis Patients

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机构: [1]Capital Med Univ, Beijing Tongren Hosp, Dept Allergy, Beijing, Peoples R China [2]Beijing Inst Otolaryngol, Beijing Lab Allerg Dis, Beijing, Peoples R China [3]Beijing Inst Otolaryngol, Beijing Key Lab Nasal Dis, Beijing, Peoples R China [4]Capital Med Univ, Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China
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关键词: Allergenic components Allergic rhinitis House dust mite Der p 23

摘要:
Introduction: House dust mite (HDM) is an important source of airborne allergens in China as it contains several allergenic components that can cause allergic rhinitis (AR) and other allergic diseases. This study aimed to determine the clinical characteristics and disease severity in AR patients sensitised to different allergenic HDM components. Methods: This was a retrospective study, which examined 129 patients who were first diagnosed with only HDM-induced AR at the Department of Allergy of Beijing Tongren Hospital from December 2019 to April 2021. Clinical characteristics and disease severity of the patients were assessed based on the sensitisation to specific Dermatophagoides pteronyssinus (Der p) and Dermatophagoides farinae (Der f) allergenic components, including Der p 1, Der p 2, Der p 23, Der f 1, and Der f 2, employing multiple correspondence analysis (MCA) with correspondence analysis chart of MCA. Results: Among HDM-induced AR cases, the positive rate of Der p 1 was the highest (87.6%), followed by Der p 2 (78.3%), Der f 2 (76.64%), Der f 1 (68.2%), and Der p 23 (37.2%). Multiple correspondence analyses showed that sensitisation to Der p 23 was associated with severe AR symptoms and asthma; sensitisation to Der p 2, Der f 1, and Der f 2 was associated with moderate AR; and no sensitisation to Der p 23 was associated with mild AR. Conclusion: Der p 23 sensitisation is prevalent in northern China and may be associated with severe symptoms and asthma in AR patients.

基金:

基金编号: Z181100001618002 Z211100002921060 IRT13082 81970849 2019-I2M-5-022 2019-10 82071022

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出版当年[2022]版:
大类 | 3 区 医学
小类 | 3 区 免疫学 4 区 过敏
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 过敏 4 区 免疫学
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出版当年[2021]版:
Q3 ALLERGY Q3 IMMUNOLOGY
最新[2023]版:
Q3 ALLERGY Q3 IMMUNOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

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第一作者机构: [1]Capital Med Univ, Beijing Tongren Hosp, Dept Allergy, Beijing, Peoples R China
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通讯机构: [1]Capital Med Univ, Beijing Tongren Hosp, Dept Allergy, Beijing, Peoples R China [2]Beijing Inst Otolaryngol, Beijing Lab Allerg Dis, Beijing, Peoples R China [3]Beijing Inst Otolaryngol, Beijing Key Lab Nasal Dis, Beijing, Peoples R China [4]Capital Med Univ, Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China
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