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Missing link between tissue specific expressing pattern of ERβ and the clinical manifestations in LGBLEL

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机构： [1]Faculty of Environment and Life, Beijing University of Technology, Beijing, China. [2]Beijing Molecular Hydrogen Research Center, Beijing, China. [3]Beijing International Science and Technology Cooperation Base of Antivirus Drug, Beijing, China. [4]Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. [5]Beijing Tongren Hospital, Capital Medical University, Beijing, China.

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关键词： LGBLEL ERb B lymphocyte proliferation lacrimal gland apoptosis clinical manifestations tumor development

摘要：

Lacrimal gland benign lymphoepithelial lesion (LGBLEL) is an IgG4-related disease of unknown etiology with a risk for malignant transformation. Estrogen is considered to be related to LGBLEL onset.Seventy-eight LGBLEL and 13 control clinical samples were collected and studied to determine the relationship between estrogen and its receptors and LGBLEL development.The serological analysis revealed no significant differences in the levels of three estrogens be-tween the LGBLEL and control groups. However, immunohistochemical analyses indicated that the expression levels of ERβ and its downstream receptor RERG were relatively lower in LGBLEL samples than in control samples, with higher expression in the lacrimal gland and lower expression in the lymphocyte infiltration region. However, low expression of ERα was detected. The transcriptome sequence analysis revealed upregulated genes associated with LGBLEL enriched in lymphocyte proliferation and activation function; downregulated genes were enriched in epithelial and vascular proliferation functions. The key genes and gene networks were further analyzed. Interactions between B cells and epithelial cells were analyzed due to the identified involvement of leukocyte subsets and epithelial cells. B cell proliferation was found to potentially contribute to lacrimal gland apoptosis.Therefore, the tissue-heterogeneous expression pattern of ERβ is potentially related to the clinical manifestations and progression of LGBLEL, although further investigations are required to confirm this finding.Copyright © 2023 Zhang, Zhao, Ma, Wu, Liu, Liu, Cai, Liu, Xie and Ma.

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出版当年[2022]版：

大类 | 3 区医学

小类 | 3 区医学：内科

最新[2023]版：

大类 | 3 区医学

小类 | 3 区医学：内科

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出版当年[2021]版：

Q2 MEDICINE, GENERAL & INTERNAL

最新[2023]版：

Q1 MEDICINE, GENERAL & INTERNAL

影响因子： 3.1 最新[2023版] 3.4 最新五年平均 5.058 出版当年[2021版] 5.493 出版当年五年平均 5.093 出版前一年[2020版] 3.9 出版后一年[2022版]

第一作者：

第一作者机构： [1]Faculty of Environment and Life, Beijing University of Technology, Beijing, China. [2]Beijing Molecular Hydrogen Research Center, Beijing, China. [3]Beijing International Science and Technology Cooperation Base of Antivirus Drug, Beijing, China.

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通讯作者：

通讯机构： [1]Faculty of Environment and Life, Beijing University of Technology, Beijing, China. [2]Beijing Molecular Hydrogen Research Center, Beijing, China. [3]Beijing International Science and Technology Cooperation Base of Antivirus Drug, Beijing, China.

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