机构:[1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China首都医科大学附属北京同仁医院研究所眼科研究所
With the increased use of artificial light and the prolonged use of optoelectronic products, light damage (LD) to the human retina has been identified as a global vision-threatening problem. While there is evidence of a significant correlation between light-induced retinal damage and age-related vision impairment in age-related macular degeneration, it is unclear how light-induced retinal degeneration manifests itself and whether there are agents capable of preventing the development of LD in the retina. This study investigated a mechanism by which blue light leads to photoreceptor death. By observing blue light exposure in retinal organoids and photoreceptor cells, we concluded that there could be significant apoptosis of the photoreceptors. We demonstrate that regenerating islet-derived 1 alpha (REG1A) prevents photoreceptors from undergoing this LD-induced apoptosis by increasing expression of the anti-apoptotic gene Bcl2 and downregulating expression of the pro-apoptotic gene Bax, resulting in reduced mitochondrial damage and improved aerobic capacity in photoreceptor cells. For the first time, REG1A has been shown to restore mitochondrial function and cell apoptosis after LD-induced damage, suggesting its potential application in the prevention and treatment of retinal vision loss.
基金:
National Natural Science Foundation of China [82125007, 82171470]; Beijing Natural Science Foundation [Z200014]
第一作者机构:[1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China
通讯作者:
通讯机构:[1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China[*1]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
推荐引用方式(GB/T 7714):
Xu Ze-Hua,Zhang Hang,Zhang Chang-Jun,et al.REG1A protects retinal photoreceptors from blue light damage[J].ANNALS OF THE NEW YORK ACADEMY OF SCIENCES.2023,1527(1):60-74.doi:10.1111/nyas.15045.
APA:
Xu, Ze-Hua,Zhang, Hang,Zhang, Chang-Jun,Yu, Si-Jian,Yuan, Jing...&Jin, Zi-Bing.(2023).REG1A protects retinal photoreceptors from blue light damage.ANNALS OF THE NEW YORK ACADEMY OF SCIENCES,1527,(1)
MLA:
Xu, Ze-Hua,et al."REG1A protects retinal photoreceptors from blue light damage".ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1527..1(2023):60-74