机构：[1]Department of Neonatology, Children's Hospital of Soochow University, Suzhou, China[2]Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Necrotizing enterocolitis (NEC) is a severe gastrointestinal disorder occurring in newborns, with a mortality rate ranging from 20 % to 30 %. The existing therapeutic approaches for NEC are limited in their effectiveness. Various factors contribute to the development of NEC, including disruption of barrier function, dysregulation of the intestinal immune system, and abnormal colonization of the intestinal microbiota. Researchers have shown considerable interest in exploring the therapeutic potential of the constituents present in human breast milk (HBM) for treating NEC. HBM contains numerous bioactive components, such as exosomes, growth factors, and oligosaccharides. However, the precise mechanisms by which HBM exerts its protective effects against NEC remain incompletely understood. In this study, our objective was to comprehensively review the bioactive substances present in HBM, aiming to facilitate the development of novel therapeutic strategies for NEC.
基金：
National Natural Sci- ence Foundation of China [81971423, 82271741, 81901512]; Shanghai Rising -Star Program [22QB1401000]
第一作者机构：[1]Department of Neonatology, Children's Hospital of Soochow University, Suzhou, China
通讯作者：
通讯机构：[1]Department of Neonatology, Children's Hospital of Soochow University, Suzhou, China[2]Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[*1]Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China[*2]Department of Neonatology, Children's Hospital of Soochow University, Suzhou 215025, China
推荐引用方式(GB/T 7714)：
Fu Changchang,Sun Wenqiang,Wang Xingyun,et al.Human breast milk: A promising treatment for necrotizing enterocolitis[J].EARLY HUMAN DEVELOPMENT.2023,184:doi:10.1016/j.earlhumdev.2023.105833.
APA：
Fu, Changchang,Sun, Wenqiang,Wang, Xingyun&Zhu, Xueping.(2023).Human breast milk: A promising treatment for necrotizing enterocolitis.EARLY HUMAN DEVELOPMENT,184,
MLA：
Fu, Changchang,et al."Human breast milk: A promising treatment for necrotizing enterocolitis".EARLY HUMAN DEVELOPMENT 184.(2023)
