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Biomedical applications of artificial exosomes for intranasal drug delivery

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收录情况： ◇ SCIE

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机构： [1]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [2]Beijing Laboratory of Allergic Diseases and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China. [3]Department of Otorhinolaryngology, Beijing Youan Hospital, Capital Medical University, Beijing, China. [4]Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [5]Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing, China.

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关键词： artificial exosomes drug delivery intranasal administration blood-brain barrier biomedical applications

摘要：

Intranasal administration offers a feasible, non-invasive method of delivering therapeutic drugs to the brain, allowing therapeutic pharmaceuticals to be administered directly to the central nervous system by bypassing the blood-brain barrier. Furthermore, exosomes are naturally occurring cell-derived nanovesicles that can serve as carriers for a variety of chemical compounds. Many studies have focused on artificial exosomes as innovative medication delivery methods. As a result, trans-nasal delivery of artificial exosomes might be employed to treat brain illnesses in a novel method. This review will outline the drug delivery mechanism of artificial extracellular vesicles, emphasize its advantages as a nasal drug carrier, particularly its application as a novel nanocarriers in brain diseases, and focus on its prospective application in chronic inflammatory nose disorders. Finally, artificial exosomes may become a unique drug delivery mode for clinical therapeutic usage.Copyright © 2023 Zhao, Yang, Jiao, Wang, Zhao and Zhang.

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出版当年[2022]版：

大类 | 2 区工程技术

小类 | 3 区综合性期刊

最新[2025]版：

大类 | 3 区生物学

小类 | 3 区生物工程与应用微生物 4 区工程：生物医学

JCR分区：

出版当年[2021]版：

Q1 MULTIDISCIPLINARY SCIENCES

最新[2023]版：

Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q2 ENGINEERING, BIOMEDICAL

影响因子： 4.3 最新[2023版] 5.1 最新五年平均 6.064 出版当年[2021版] 6.303 出版当年五年平均 5.89 出版前一年[2020版] 5.7 出版后一年[2022版]

第一作者：

第一作者机构： [1]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [2]Beijing Laboratory of Allergic Diseases and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China.

共同第一作者：

通讯作者：

通讯机构： [1]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [2]Beijing Laboratory of Allergic Diseases and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China. [4]Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [5]Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing, China.

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Biomedical applications of artificial exosomes for intranasal drug delivery

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