机构：[1]Hongqiao International Institute of Medicine, Tongren Hospital and State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China[2]Department of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China[3]Institute of Interdisciplinary Integrative Biomedical Research, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China[4]Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, United States
Liposomal drug delivery for cancer therapy can be limited due to drug leakage in circulation. Here, we develop a new method to enhance the stability of actively loaded liposomal doxorubicin (DOX) through embedding a stiff nanobowl in the liposomal water cavity. Nanobowl-supported liposomal DOX (DOX@NbLipo) resists the influence of plasma protein and blood flow shear force to prevent drug leakage. This approach yields improved drug delivery to tumor sites and enhanced antitumor efficacy. Compared to alternative methods of modifying liposome surface and composition for stability, this approach designs a physical support for an all-aqueous nanoliposomal cavity. Nanobowl stabilization of liposomes is a simple and effective method to improve carrier stability and drug delivery.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81572998, 81773274]; Shanghai Municipal Science and Technology CommissionScience & Technology Commission of Shanghai Municipality (STCSM) [16520710700]; "Shu Guang" Program of Shanghai Education Development Foundation; Shanghai Municipal Education CommissionShanghai Municipal Education Commission (SHMEC) [16SG13]
第一作者机构：[1]Hongqiao International Institute of Medicine, Tongren Hospital and State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
共同第一作者：
通讯作者：
通讯机构：[1]Hongqiao International Institute of Medicine, Tongren Hospital and State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China[4]Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, United States[*1]Hongqiao International Institute of Medicine, Tongren Hospital and State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China[*2]Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, United States
推荐引用方式(GB/T 7714)：
Chen Zhong-Jian,Yang Si-Cong,Liu Xue-Liang,et al.Nanobowl-Supported Liposomes Improve Drug Loading and Delivery[J].NANO LETTERS.2020,20(6):4177-4187.doi:10.1021/acs.nanolett.0c00495.
APA：
Chen, Zhong-Jian,Yang, Si-Cong,Liu, Xue-Liang,Gao, Yuhao,Dong, Xiao...&Fang, Chao.(2020).Nanobowl-Supported Liposomes Improve Drug Loading and Delivery.NANO LETTERS,20,(6)
MLA：
Chen, Zhong-Jian,et al."Nanobowl-Supported Liposomes Improve Drug Loading and Delivery".NANO LETTERS 20..6(2020):4177-4187
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