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Versatile PLGA-Based Drug Delivery Systems for Tumor Immunotherapy

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机构: [1]State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China. [2]School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China. [3]Department of Gastroenterology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, P. R. China.
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关键词: controlled release immunogenic cell death PLGA targeted delivery tumor immunotherapy tumor microenvironment tumor vaccine

摘要:
Tumor immunotherapy, which utilizes the immune system to fight cancer, represents a revolutionary method for cancer treatment. Poly (lactic-co-glycolic acid) (PLGA) copolymer has emerged as a promising material for tumor immunotherapy due to its biocompatibility, biodegradability, and versatility in drug delivery. By tuning the size, shape, and surface properties of PLGA-based systems, researchers have improved their ability to align with the requirements for diverse tumor immunotherapy modalities. In this review, the basic properties of the PLGA materials are first introduced and further the principal forms of the PLGA systems for controlled release are summarized and delivery applications are targeted. In addition, recent advances in the use of PLGA delivery systems are highlighted to enhance antitumor immune responses in terms of tumor vaccines, immunogenic cell death-mediated immune responses, tumor microenvironment modulation, and combination immunotherapies. Finally, prospects for the future research and clinical translation of PLGA materials are proposed.© 2025 Wiley‐VCH GmbH.

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出版当年[2025]版:
大类 | 2 区 材料科学
小类 | 2 区 材料科学:综合 3 区 纳米科技
最新[2025]版:
大类 | 2 区 材料科学
小类 | 2 区 材料科学:综合 3 区 纳米科技
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出版当年[2023]版:
Q1 CHEMISTRY, PHYSICAL Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Q1 NANOSCIENCE & NANOTECHNOLOGY
最新[2023]版:
Q1 CHEMISTRY, PHYSICAL Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Q1 NANOSCIENCE & NANOTECHNOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者:
第一作者机构: [1]State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China. [2]School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
通讯作者:
通讯机构: [1]State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China. [2]School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
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