Hybrid manganese dioxide-bovine serum albumin nanostructure incorporated with doxorubicin and IR780 for enhanced breast cancer chemo-photothermal therapy
机构：[1]School of Pharmacy, Sichuan Province College Key Laboratory of Structure-Specific Small Molecule Drugs, Chengdu Medical College, Chengdu, China[2]Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
The therapeutic outcome of chemotherapy is limited, although it is still the preferent strategy for cancer therapy. By regulation of tumor microenvironment and introduction of another therapeutic manner for combination therapy can enhance the anticancer activity of chemotherapeutics. Herein, we have constructed a hybrid nanostructure which composed of manganese dioxide (MnO2) and doxorubicin (DOX) as well as IR780 by stabilizing with BSA (BMDI) in one-pot procedure to alleviate tumor hypoxia and enhance tumor growth inhibition. The MnO2 can react with H2O2 to generate oxygen, and additionally react with GSH to realize tumor microenvironment responsive drug controlled release. And the release Mn ions further enhanced the magnetic resonance signal which made the BMDI a promising contrast agent for MRI. Moreover, the introduction of MnO2 has enhanced the anticancer activity of DOX in vitro and in vivo, and efficiently suppressed the tumor growth. By further introducing with photothermal therapy (PTT), the tumor growth was almost inhibited. It demonstrated that the BMDI hybrid nanostructure has great potential in tumor growth inhibition as therapeutics carrier.
基金：
National Natural Science
Foundation of China (grant numbers NSFC31600811, 81602184); the
China Postdoctoral Science Foundation (grant numbers 2018M643486);
the Scientific Research Foundation for the Returned Overseas Chinese
Scholars, Sichuan Province, China; the Research Project of Innovative
Research Team in Chengdu Medical College (grant number CYTD18-05).
第一作者机构：[1]School of Pharmacy, Sichuan Province College Key Laboratory of Structure-Specific Small Molecule Drugs, Chengdu Medical College, Chengdu, China
通讯作者：
通讯机构：[1]School of Pharmacy, Sichuan Province College Key Laboratory of Structure-Specific Small Molecule Drugs, Chengdu Medical College, Chengdu, China[2]Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[*1]School of Pharmacy, Sichuan Province College Key Laboratory of Structure- Specific Small Molecule Drugs, Chengdu Medical College, Chengdu, China[*2]Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
推荐引用方式(GB/T 7714)：
Yuan Xiao,Yin Yanlong,Zan Wang,et al.Hybrid manganese dioxide-bovine serum albumin nanostructure incorporated with doxorubicin and IR780 for enhanced breast cancer chemo-photothermal therapy[J].DRUG DELIVERY.2019,26(1):1254-1264.doi:10.1080/10717544.2019.1693706.
APA：
Yuan, Xiao,Yin, Yanlong,Zan, Wang,Sun, Xiyang&Yang, Qian.(2019).Hybrid manganese dioxide-bovine serum albumin nanostructure incorporated with doxorubicin and IR780 for enhanced breast cancer chemo-photothermal therapy.DRUG DELIVERY,26,(1)
MLA：
Yuan, Xiao,et al."Hybrid manganese dioxide-bovine serum albumin nanostructure incorporated with doxorubicin and IR780 for enhanced breast cancer chemo-photothermal therapy".DRUG DELIVERY 26..1(2019):1254-1264
医学