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Autophagy regulation by microRNAs in chemotherapy resistance

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机构: [1]Qingdao Univ, Dept Otolaryngol, Affiliated Hosp, 16 Jiangsu Rd, Qingdao 266000, Shandong, Peoples R China [2]Capital Med Univ, Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100730, Peoples R China
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关键词: cancer autophagy miRNA chemotherapy resistance

摘要:
Chemotherapy, as an adjuvant therapy, utilizes drugs to treat cancer, and resistance to therapeutic drugs limits the efficacy of chemotherapy treatments. Several mechanisms have been proposed to improve the effect of tumor chemotherapy in order to overcome drug resistance. Among these, autophagy mediated by microRNAs (miRNAs) is one of the primary mechanisms. A large number of molecules targeted by miRNAs are involved in each step of the autophagic pathway. Recent advancement in chemotherapy research has revealed that miRNAs involved in the autophagy process target some of these molecules, thereby influencing the therapeutic effect of chemotherapy drugs. Thus, miRNAs appear to be potential tools or targets with which to suppress tumor growth and should be studied in further details for their clinical application against drug resistance.

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出版当年[2019]版:
大类 | 3 区 医学
小类 | 4 区 肿瘤学
最新[2023]版:
大类 | 3 区 医学
小类 | 4 区 肿瘤学
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出版当年[2018]版:
Q2 ONCOLOGY
最新[2023]版:
Q2 ONCOLOGY

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第一作者机构: [1]Qingdao Univ, Dept Otolaryngol, Affiliated Hosp, 16 Jiangsu Rd, Qingdao 266000, Shandong, Peoples R China
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通讯机构: [1]Qingdao Univ, Dept Otolaryngol, Affiliated Hosp, 16 Jiangsu Rd, Qingdao 266000, Shandong, Peoples R China [*1]Department of Otolaryngology, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, Shandong 266000, P.R. China
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