Neutralization against Omicron subvariants after BA.5/BF.7 breakthrough infection weakened as virus evolution and aging despite repeated prototype-based vaccination
机构：[1]Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Shanghai Medical College, Fudan University, China.[2]Institute of Infectious Disease and Biosecurity, State Key Laboratory of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University, Shanghai, China.[3]Geriatric department, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.[4]Community Health Service Center of Huaxin Town, Qingpu District, Shanghai, China.[5]Community Health Service Center of Chonggu Town, Qingpu District, Shanghai, China.[6]Community Health Service Center of Baihe Street, Qingpu District, Shanghai, China.[7]Community Health Service Center of Xianghuaqiao Street, Qingpu District, Shanghai, China.[8]Shanghai High School International Division, Shanghai, China.[9]Shanghai Pinghe Bilingual School, Shanghai, China.[10]Shanghai Huashen Institute of Microbes and Infections, NO.6 Lane 1220 Huashan Rd. Shanghai, China.[11]National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.[12]Key Laboratory of Medical Molecular Virology (MOE/MOH), Shanghai Medical College, Fudan University, Shanghai, China.
Omicron had swept the mainland China between December 2022 and January 2023, while SARS-CoV-2 still continued to evolve. To fully prepare for the next wave, it's urgent to evaluate the humoral immune response post BA.5/BF.7 breakthrough infection against predominant sublineages among existing vaccination strategies and the elders.This study enrolled a longitudinal young-adult cohort from 2/3-dose vaccination to 1 month after breakthrough infection, and an elder cohort at 1 month after breakthrough infection. Seral samples were collected and tested for humoral immune response to SARS-CoV-2 subvariants including WT, BA.2, BA.5, BF.7, BQ.1.1, CH.1.1, XBB.1.5.BA.5/BF.7 breakthrough infection induced higher neutralization activity than solely vaccination in all SARS-CoV-2 strains, while the latest Omicron subvariants, BQ.1.1, CH.1.1, XBB.1.5, exhibited the strongest neutralization evasion ability. There was a negative correlation between age and humoral immune response in WT, BA.5, BQ.1.1, and XBB.1.5. Compared to non-vaccination groups, breakthrough infection in two-dose vaccination groups had significantly higher neutralizing antibody against WT, BA.2, BA.5, BF.7 but not to BQ.1.1, CH.1.1, XBB.1.5., while booster dose against the prototype prior-breakthrough would not further significantly enhance individual's humoral responses against the latest Omicron subvariants.Newer variants manifest increasing immune evasion from neutralization and repeated prototype-based booster vaccines may not further enhance neutralizing antibody against emerging new variants. Older adults have lower levels of neutralizing antibody. Future vaccination strategies should aim to enhance effective neutralization to contemporary variants.
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外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|2 区医学
小类|2 区微生物学2 区免疫学2 区传染病学
最新[2025]版：
大类|1 区医学
小类|1 区传染病学1 区微生物学2 区免疫学
第一作者：
第一作者机构：[1]Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Shanghai Medical College, Fudan University, China.
共同第一作者：
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推荐引用方式(GB/T 7714)：
Wang Hongyu,Xue Quanlin,Zhang Haocheng,et al.Neutralization against Omicron subvariants after BA.5/BF.7 breakthrough infection weakened as virus evolution and aging despite repeated prototype-based vaccination[J].Emerging microbes & infections.2023,2249121.doi:10.1080/22221751.2023.2249121.
APA：
Wang Hongyu,Xue Quanlin,Zhang Haocheng,Yuan Guanmin,Wang Xun...&Zhang Wenhong.(2023).Neutralization against Omicron subvariants after BA.5/BF.7 breakthrough infection weakened as virus evolution and aging despite repeated prototype-based vaccination.Emerging microbes & infections,,
MLA：
Wang Hongyu,et al."Neutralization against Omicron subvariants after BA.5/BF.7 breakthrough infection weakened as virus evolution and aging despite repeated prototype-based vaccination".Emerging microbes & infections .(2023):2249121
医学