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The early-phase transcriptome and the clinical efficacy analysis in three modes of subcutaneous immunotherapy for allergic rhinitis

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收录情况： ◇ SCIE

作者：
Huang Jingyu[1] * ; Zhang Wei[1] * ; Xiang Rong[1] * ; Tan Lu[1] ; Liu Peiqiang[1] ; Tao Zezhang[1,2] ; Deng Yuqin[1,*1] ; Tong Huan[3,*2] ; Xu Yu[1,4,2,*1] ;
机构： [1]Department of Rhinology and Allergy, OtolaryngologyHead and Neck Surgery Center, Renmin Hospital of Wuhan University, Wuhan, China. [2]Hubei Province Key Laboratory of Allergy and Immunology, Wuhan, China. [3]Wound Repair＆Rehabilitation Center Department, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Wuhan, China. [4]Research Institute of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
出处：
DOI： 10.1016/j.waojou.2023.100811
ISSN：

关键词： Allergic rhinitis Gene expression profiles Gene expression array Subcutaneous immunotherapy

摘要：
Allergen immunotherapy is the only etiological treatment for allergic rhinitis.To analyze the efficacy, safety, and mechanism of subcutaneous immunotherapy (SCIT).The efficacy, safety, and serum immunological changes of 3 modes of subcutaneous immunotherapy were compared. Peripheral blood mononuclear cells (PBMC) transcriptome changes were obtained on the Illumina sequencing platforms. We confirmed differentially expressed genes (DEGs) by quantitative real-time polymerase chain reaction (PCR). The DEGs were analyzed by gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and protein-protein interaction (PPI) networks. The correlation between the common DEGs and clinical indicators was analyzed by Origin 2022.The 3 SCITs were all effective after 1 year. The Combined Symptom and Medication Score (CSMS) and Visual Analog Score (VAS) in rush immunotherapy (RIT) are lowest after 24 and 48 weeks of treatment among the 3 groups. After treatment, the levels of sIgE, sIgE/tIgE, Th2 cytokines, Th17 cytokines, and percentage of peripheral eosinophils (EOS%) decreased significantly (P＜0.05), while the levels of Th1 type cytokines did not change significantly. Transcriptome analysis identified 24, 24, and 91 DEGs at W3 and 42, 52, 175 DEGs at W7 in conventional immunotherapy (CIT), cluster immunotherapy (CLIT), and RIT groups, respectively. The pathways and functions involved in SCIT include secretion of Th1/2 cytokines, immune cell differentiation. Unlike CIT and CLIT, DEGs are also involved in T cell tolerance induction, T cell anergy, and lymphocyte anergy in RIT. CXCR1, CXCR2, and IER3 had a specific effect on reflecting the improvement of symptoms in allergic rhinitis patients with SCIT.The clinical efficacy of RIT appeared earlier than CIT and CLIT. Clinicians can use the highly conserved gene expression profile to evaluate responses to immunotherapy.© 2023 The Authors.

基金：
National Natural Science Foundation of China (NSFC): No. 82271134 (Yu Xu); No. 81770986 (Yu Xu); No. 82071017 (Yu Xu) and funded by the Fundamental Research Funds for the Central Universities: No. 2042020kf1044 (Yu Xu); 2042022kf1113 (Wei Zhang).
语种：
外文
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WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 医学
小类 | 3 区 过敏 3 区 免疫学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 过敏 2 区 免疫学
JCR分区：
出版当年[2021]版：
Q2 ALLERGY Q2 IMMUNOLOGY
最新[2023]版：
Q2 ALLERGY Q2 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Rhinology and Allergy, OtolaryngologyHead and Neck Surgery Center, Renmin Hospital of Wuhan University, Wuhan, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Rhinology and Allergy, OtolaryngologyHead and Neck Surgery Center, Renmin Hospital of Wuhan University, Wuhan, China. [2]Hubei Province Key Laboratory of Allergy and Immunology, Wuhan, China. [3]Wound Repair＆Rehabilitation Center Department, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Wuhan, China. [4]Research Institute of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, China. [*1]Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan 430060, China [*2]Tongren Hospital of Wuhan University, 241 Peng Liuyang Road, Wuhan 430060, China
推荐引用方式(GB/T 7714)：
Huang Jingyu,Zhang Wei,Xiang Rong,et al.The early-phase transcriptome and the clinical efficacy analysis in three modes of subcutaneous immunotherapy for allergic rhinitis[J].WORLD ALLERGY ORGANIZATION JOURNAL.2023,16(8):doi:10.1016/j.waojou.2023.100811.
APA：
Huang Jingyu,Zhang Wei,Xiang Rong,Tan Lu,Liu Peiqiang...&Xu Yu.(2023).The early-phase transcriptome and the clinical efficacy analysis in three modes of subcutaneous immunotherapy for allergic rhinitis.WORLD ALLERGY ORGANIZATION JOURNAL,16,(8)
MLA：
Huang Jingyu,et al."The early-phase transcriptome and the clinical efficacy analysis in three modes of subcutaneous immunotherapy for allergic rhinitis".WORLD ALLERGY ORGANIZATION JOURNAL 16..8(2023)

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