个人科研网厅 | | 帮助
高级检索
当前位置： 首页 > 详情页

Targeting non-muscle myosin II inhibits proliferative vitreoretinopathy through regulating epithelial-mesenchymal transition

| 认领 | 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Jiang Haiping[1,3,5] * ; Chen Yuning[2] * ; He Zhengquan[1,3,4,5] * ; Li Jie[1,3,5] * ; Gao Qingqin[1,3,5] ; Li Wei[1,3,4,5] ; Wei Wenbin[2] ; Zhang Ying[1,3,4,5,*1] ;
机构： [1]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China [2]Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China [3]Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, 100101, China [4]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China [5]University of Chinese Academy of Sciences, Beijing, 100049, China
出处：
DOI： 10.1016/j.bbrc.2023.149149
ISSN：

关键词： Proliferative vitreoretinopathy Blebbistatin Retinal pigment epithelium Epithelial-mesenchymal transformation

摘要：
Proliferative vitreoretinopathy (PVR) is a common complication of rhegmatogenous retinal detachment, eventually leading to vision loss. To date, there are no effective drugs for the treatment of this disease. In this study, we investigated the effect of blebbistatin, a non-muscle myosin II inhibitor, on the ARPE-19 cell line and in a rabbit model of proliferative vitreoretinopathy. In vitro, we found that blebbistatin inhibited the epithelial-mesenchymal transition of retinal pigment epithelial (RPE) cells and inhibited the ability of RPE cells to migrate, proliferate, generate extracellular matrix, and affect contractility. In vivo the PVR model showed that blebbistatin significantly delayed PVR progression. It also partially prevents the loss of retinal function caused by PVR. Our results suggest that blebbistatin is a potential drug with clinical applications for the treatment of PVR.Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

基金：
The authors appreciate the donation of ARPE-19 cells from Jiarui Li(Peking University People's Hospital). This work was supported by the National Key Research and Development Program (2018YFE0201100,2019YFA0110800，2020YFA0707900，201 9YFA0110100 and 2019YFA0903800); the CAS Project for Young Scientists in Basic Research (YSBR-012); the National Natural Science Foundation of China (32071456，82220108017, 82141128); The Capital Health Research and Development of Special (2020-1 -2052); Science & Technology Project of Beijing Municipal Science & Technology Commission (Z201100005520045, Z181100001 818003).
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 4 区 生物学
小类 | 4 区 生化与分子生物学 4 区 生物物理
最新[2023]版：
大类 | 3 区 生物学
小类 | 3 区 生物物理 4 区 生化与分子生物学
JCR分区：
出版当年[2021]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS
最新[2023]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China [3]Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, 100101, China [5]University of Chinese Academy of Sciences, Beijing, 100049, China
共同第一作者：
通讯作者：
通讯机构： [1]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China [3]Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing, 100101, China [4]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China [5]University of Chinese Academy of Sciences, Beijing, 100049, China [*1]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China
推荐引用方式(GB/T 7714)：
Jiang Haiping,Chen Yuning,He Zhengquan,et al.Targeting non-muscle myosin II inhibits proliferative vitreoretinopathy through regulating epithelial-mesenchymal transition[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2023,686:149149.doi:10.1016/j.bbrc.2023.149149.
APA：
Jiang Haiping,Chen Yuning,He Zhengquan,Li Jie,Gao Qingqin...&Zhang Ying.(2023).Targeting non-muscle myosin II inhibits proliferative vitreoretinopathy through regulating epithelial-mesenchymal transition.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,686,
MLA：
Jiang Haiping,et al."Targeting non-muscle myosin II inhibits proliferative vitreoretinopathy through regulating epithelial-mesenchymal transition".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 686.(2023):149149

相关文献

[1]增生性玻璃体视网膜病变研究进展 [2]Intraretinal Retinal Pigment Epithelium Cells in Age-Related Macular Degeneration [3]Intraretinal Retinal Pigment Epithelium Cells in Age-Related Macular Degeneration [4]Thickness of retinal pigment epithelium-Bruch's membrane complex in adult Chinese using optical coherence tomography [5]Reversibility of Retinal Pigment Epithelium Detachment Parallel to Acute Intraocular Pressure Rise [6]Acute Peripapillary Retinal Pigment Epithelium Changes Associated with Acute Intraocular Pressure Elevation [7]Acute Peripapillary Retinal Pigment Epithelium Changes Associated with Acute Intraocular Pressure Elevation [8]视网膜色素上皮细胞特异性吞噬功能的研究 [9]MiR-29a-3p inhibits high-grade transformation and epithelial-mesenchymal transition of lacrimal gland adenoid cystic carcinoma by targeting Quaking [10]ROCK inhibitor enhances mitochondrial transfer via tunneling nanotubes in retinal pigment epithelium

资源点击量：21169 今日访问量：0 总访问量：1219 更新日期：2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学附属北京同仁医院 技术支持：重庆聚合科技有限公司 地址：北京市东城区东交民巷1号(100730)