Purpose Retinal pigment epithelium (RPE) adenoma is a rare intraocular benign tumor. It is almost always misdiagnosed as uveal melanoma (UM) resulting in inappropriate management. The purpose of this study was to investigate MRI features of the RPE adenoma that may help differentiate this entity from UM. Methods MRI was performed in eight patients with pathology-proven RPE adenoma, five of whom had dynamic contrast-enhanced (DCE) MRI. The time-intensity curves (TIC) of all DCE-MRI were evaluated, and the maximum contrast index (CImax) were calculated. Results All eight tumors showed well-defined margins. They were homogeneously hyperintense on T1WI and hypointense on T2WI compared to vitreous body. An oval mass was seen in five tumors, lentiform in two tumors, and placoid-shaped in one tumor. After contrast administration, mild enhancement was identified in five tumors and moderate enhancement in three tumors. In all five tumors, DCE-MRI exhibited a plateau-shaped TIC with a median CImax of 0.37. A "dark-linear sign" (defined as low signal intensity linear zone located between tumor and enhanced choroid on post contrast T1WI with fat-suppression) was noted in all eight patients with RPE adenoma. Conclusion RPE adenoma and UM often have similar MR imaging findings. This study reports for the first time a "dark-linear sign" on post contrast T1WI with fat-suppression seen in RPE adenoma. This observation may be characteristic of RPE adenoma and may help separate this entity from UM.
基金：
Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (CN) [ZYLX201704] Funding Source: Medline; Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment [2016YNZL03] Funding Source: Medline; Beijing Municipal Administration of Hospitals' Ascent Plan [DFL20190203] Funding Source: Medline; High Level Health Technical Personnel of Bureau of Health in Beijing [2014-2-005] Funding Source: Medline
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区医学
小类|3 区核医学4 区临床神经病学4 区神经成像
最新[2025]版：
大类|3 区医学
小类|3 区神经成像3 区核医学4 区临床神经病学
JCR分区：
出版当年[2018]版：
Q2NEUROIMAGINGQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ3CLINICAL NEUROLOGY
最新[2023]版：
Q2CLINICAL NEUROLOGYQ2NEUROIMAGINGQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Radiol, Beijing, Beijing, Peoples R China[2]Capital Med Univ, Clin Ctr Eye Tumors, Beijing, Beijing, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Radiol, Beijing, Beijing, Peoples R China[2]Capital Med Univ, Clin Ctr Eye Tumors, Beijing, Beijing, Peoples R China
推荐引用方式(GB/T 7714)：
Su Yaping,Xu Xiaolin,Wei Wenbin,et al.Using a novel MR imaging sign to differentiate retinal pigment epithelium from uveal melanoma[J].NEURORADIOLOGY.2020,62(3):347-352.doi:10.1007/s00234-019-02353-3.
APA：
Su, Yaping,Xu, Xiaolin,Wei, Wenbin&Xian, Junfang.(2020).Using a novel MR imaging sign to differentiate retinal pigment epithelium from uveal melanoma.NEURORADIOLOGY,62,(3)
MLA：
Su, Yaping,et al."Using a novel MR imaging sign to differentiate retinal pigment epithelium from uveal melanoma".NEURORADIOLOGY 62..3(2020):347-352
