机构：[1]Department of Neurosurgery, Yixing People's hospital, Yixing Jiangsu214200, China.[2]Department of Pharmaceutical, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, Hubei430060, China.[3]Department of Outpatient, General Hospital of Western Theater of Chinese People's Liberation Army, Chengdu, Sichuan 610000, China.[4]Department of Neurology, The Second Hospital of Dalian Medical University, Dalian, Liaoning116000, China.
A suitable exercise program helps to improve physiological performance and improves aerobic capacity, blood absorption, and sufficient oxygen for the brain and muscles. This study investigated the effect of endurance training and adenosine drug injection on the MCP-1 gene after cerebral ischemia and perfusion in male rats. For this purpose, 48 male Wistar rats were selected, and after ischemic induction, they were placed in endurance training/adenosine/ischemia, ischemia/adenosine, endurance training/ischemia, and control/ischemia groups. After induction of ischemia, an endurance exercise protocol was performed. Real-Time PCR technique was used to evaluate monocyte chemotactic protein-1 (MCP-1) gene expression. The results showed a significant difference between the control/ischemia group and the adenosine/ischemia group in the expression of the MCP-1 gene among male rats. Also, there was a significant difference in MCP-1 gene expression between the control/ischemia group and the endurance exercise/ischemia group. On the other hand, there was no significant difference between the control/ischemia group and the endurance training/adenosine/ischemia group in MCP-1 gene expression in ischemia-reperfusion male rats. Overall, it is likely that preconditioning with endurance exercise and adenosine drug up-regulates MCP-1 gene expression before the ischemic stroke. Therefore, training and adenosine may be helpful as preventive stimuli against ischemic stroke.
基金：
Project supported by Hainan Province Clinical Medical Center.
第一作者机构：[1]Department of Neurosurgery, Yixing People's hospital, Yixing Jiangsu214200, China.
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推荐引用方式(GB/T 7714)：
Zhou Liping,Chen Jiajia,Dong Xu,et al.The role of endurance exercise and adenosine on monocyte chemotactic protein-1 (MCP-1) gene expression in male rat brain ischemia-reperfusion[J].CELLULAR AND MOLECULAR BIOLOGY.2023,69(10):82-87.doi:10.14715/cmb/2023.69.10.11.
APA：
Zhou Liping,Chen Jiajia,Dong Xu&Yi Yang.(2023).The role of endurance exercise and adenosine on monocyte chemotactic protein-1 (MCP-1) gene expression in male rat brain ischemia-reperfusion.CELLULAR AND MOLECULAR BIOLOGY,69,(10)
MLA：
Zhou Liping,et al."The role of endurance exercise and adenosine on monocyte chemotactic protein-1 (MCP-1) gene expression in male rat brain ischemia-reperfusion".CELLULAR AND MOLECULAR BIOLOGY 69..10(2023):82-87
