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Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci

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收录情况： ◇ SCIE

作者：
Lisa de las Fuentes[1,2] * ; Karen L. Schwander[2,3] * ; Michael R. Brown[4] * ; Amy R. Bentley[5] * ; Thomas W. Winkler[6] * ; Yun Ju Sung[2,7] * ; Patricia B. Munroe[8,9] * ; Clint L. Miller[10,11,12] * ; Hugo Aschard[13,14] ; Stella Aslibekyan[15] ; Traci M. Bartz[16,17] ; Lawrence F. Bielak[18] ; Jin Fang Chai[19] ; Ching-Yu Cheng[20,21] ; Rajkumar Dorajoo[22] ; Mary F. Feitosa[3] ; Xiuqing Guo[23] ; Fernando P. Hartwig[24,25] ; Andrea Horimoto[26] ; Ivana Kolčić[27,28] ; Elise Lim[29] ; Yongmei Liu[30] ; Alisa K. Manning[31,32] ; Jonathan Marten[33] ; Solomon K. Musani[34] ; Raymond Noordam[35] ; Sandosh Padmanabhan[36] ; Tuomo Rankinen[37] ; Melissa A. Richard[38] ; Paul M. Ridker[39,40] ; Albert V. Smith[41,42] ; Dina Vojinovic[43,44] ; Alan B. Zonderman[45,46] ; Maris Alver[47] ; Mathilde Boissel[48,49] ; Kaare Christensen[50] ; Barry I. Freedman[51] ; Chuan Gao[52] ; Franco Giulianini[39] ; Sarah E. Harris[53,54] ; Meian He[55] ; Fang-Chi Hsu[56] ; Brigitte Kühnel[57,58] ; Federica Laguzzi[59] ; Xiaoyin Li[60,61] ; Leo-Pekka Lyytikäinen[62,63] ; Ilja M. Nolte[64] ; Alaitz Poveda[65] ; Rainer Rauramaa[66] ; Muhammad Riaz[67,68] ; Antonietta Robino[69] ; Tamar Sofer[70] ; Fumihiko Takeuchi[71] ; Bamidele O. Tayo[72] ; Peter J. van der Most[73] ; Niek Verweij[74] ; Erin B. Ware[75] ; Stefan Weiss[76,77] ; Wanqing Wen[78] ; Lisa R. Yanek[79] ; Yiqiang Zhan[80] ; Najaf Amin[43] ; Dan E. Arking[81] ; Christie Ballantyne[82,83] ; Eric Boerwinkle[4,84] ; Jennifer A. Brody[16] ; Ulrich Broeckel[85] ; Archie Campbell[86,87] ; Mickaël Canouil[48,49] ; Xiaoran Chai[88] ; Yii-Der Ida Chen[23] ; Xu Chen[80] ; Kumaraswamy Naidu Chitrala[45] ; Maria Pina Concas[69] ; Ulf de Faire[59] ; Renée de Mutsert[89] ; H. Janaka de Silva[90] ; Paul S. de Vries[4] ; Ahn Do[2,3] ; Jessica D. Faul[75] ; Virginia Fisher[29] ; James S. Floyd[16] ; Terrence Forrester[91] ; Yechiel Friedlander[92] ; Giorgia Girotto[69] ; C. Charles Gu[2] ; Göran Hallmans[93] ; Sami Heikkinen[94] ; Chew-Kiat Heng[95,96] ; Georg Homuth[76] ; Steven Hunt[97,98] ; M. Arfan Ikram[43] ; David R. Jacobs Jr[99] ; Maryam Kavousi[43] ; Chiea Chuen Khor[22] ; Tuomas O. Kilpeläinen[100,101] ; Woon-Puay Koh[102,103] ; Pirjo Komulainen[66] ; Carl D. Langefeld[56] ; Jingjing Liang[60] ; Kiang Liu[104] ; Jianjun Liu[22] ; Kurt Lohman[30] ; Reedik Mägi[47] ; Ani W. Manichaikul[10] ; Colin A. McKenzie[91] ; Thomas Meitinger[105,106] ; Yuri Milaneschi[107] ; Matthias Nauck[77,108] ; Christopher P. Nelson[67,68] ; Jeffrey R. O’Connell[109,110] ; Nicholette D. Palmer[111] ; Alexandre C. Pereira[26] ; Thomas Perls[112] ; Annette Peters[58,113] ; Ozren Polašek[27,28] ; Olli T. Raitakari[114,115,116] ; Kenneth Rice[17] ; Treva K. Rice[2] ; Stephen S. Rich[10] ; Charumathi Sabanayagam[20,21] ; Pamela J. Schreiner[99] ; Xiao-Ou Shu[78] ; Stephen Sidney[117] ; Mario Sims[34] ; Jennifer A. Smith[18,75] ; John M. Starr[54,119] ; Konstantin Strauch[120,121] ; E. Shyong Tai[19,122,123] ; Kent D. Taylor[23] ; Michael Y. Tsai[124] ; André G. Uitterlinden[43,125] ; Diana van Heemst[35] ; Melanie Waldenberger[57,58,126] ; Ya-Xing Wang[127] ; Wen-Bin Wei[127] ; Gregory Wilson[128] ; Deng Xuan[29] ; Jie Yao[23] ; Caizheng Yu[55] ; Jian-Min Yuan[129,130] ; Wei Zhao[18] ; Diane M. Becker[79] ; Amélie Bonnefond[48,49,131] ; Donald W. Bowden[111] ; Richard S. Cooper[72] ; Ian J. Deary[53,54] ; Jasmin Divers[56] ; Tõnu Esko[47,132] ; Paul W. Franks[65,133,134] ; Philippe Froguel[48,49,131] ; Christian Gieger[57,135] ; Jost B. Jonas[127,136,137] ; Norihiro Kato[71] ; Timo A. Lakka[66,94,138] ; Karin Leander[59] ; Terho Lehtimäki[62,63] ; Patrik K. E. Magnusson[80] ; Kari E. North[139] ; Ioanna Ntalla[8,140] ; Brenda Penninx[107] ; Nilesh J. Samani[67,68] ; Harold Snieder[64] ; Beatrice Spedicati[141] ; Pim van der Harst[142] ; Henry Völzke[77,143] ; Lynne E. Wagenknecht[56] ; David R. Weir[75] ; Mary K. Wojczynski[3] ; Tangchun Wu[55] ; Wei Zheng[78] ; Xiaofeng Zhu[60] ; Claude Bouchard[37] ; Daniel I. Chasman[39,40] ; Michele K. Evans[45,144] ; Ervin R. Fox[145] ; Vilmundur Gudnason[42,146] ; Caroline Hayward[33] ; Bernardo L. Horta[24] ; Sharon L. R. Kardia[18] ; Jose Eduardo Krieger[26] ; Dennis O. Mook-Kanamori[89,147] ; Patricia A. Peyser[18] ; Michael M. Province[3] ; Bruce M. Psaty[16,148,149] ; Igor Rudan[150] ; Xueling Sim[19] ; Blair H. Smith[151] ; Rob M. van Dam[19,152] ; Cornelia M. van Duijn[43,153] ; Tien Yin Wong[20,21] ; Donna K. Arnett[154] ; Dabeeru C. Rao[2] ; James Gauderman[155] ; Ching-Ti Liu[29] ; Alanna C. Morrison[4] ; Jerome I. Rotter[23] ; Myriam Fornage[4,38] ;
机构： [1]Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St.Louis, MO, United States [2]Division of Biostatistics, Washington University School of Medicine, St.Louis, MO, United States [3]Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St.Louis, MO, United States [4]Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, United States [5]Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, United States [6]Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany [7]Department of Psychiatry, Washington University School of Medicine,St.Louis, MO, United States [8]Clinical Pharmacology, Queen Mary University of London, London, United Kingdom [9]National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, United Kingdom [10]Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, United States [11]Biochemistry and Molecular Genetics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, United States [12]Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, United States [13]Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States [14]Département de Génomes et Génétique, Institut Pasteur de Lille, Université de Lille, Lille, France [15]School of Public Health, Epidemiology, University of Alabama at Birmingham, Birmingham, AL, United States [16]Cardiovascular Health Research Unit, University of Washington, Seattle, WA, United States [17]Department of Biostatistics, University of Washington, Seattle, WA, United States [18]Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, United States [19]Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore [20]Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore [21]Ophthalmology and Visual Sciences Academic Clinical Program, Medical School, Duke-National University of Singapore, Singapore, Singapore [22]Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore [23]Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Los Angeles, CA, United States [24]Postgraduate Programme in Epidemiology, Faculty of Medicine, Federal University of Pelotas, Pelotas, RS, Brazil [25]Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom [26]Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of Sao Paulo Medical School, Sao Paulo, SP, Brazil [27]University of Split School of Medicine, Split, Croatia [28]Algebra University College, Zagreb, Croatia [29]Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States [30]Division of Cardiology, Department of Medicine, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, United States [31]Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, United States [32]Department of Medicine, Harvard Medical School, Boston, MA, United States [33]Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom [34]Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, United States [35]Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, Netherlands [36]Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom [37]Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, United States [38]Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, United States [39]Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, United States [40]Harvard Medical School, Boston, MA, United States [41]Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, United States [42]Icelandic Heart Association, Kopavogur, Iceland [43]Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, Netherlands [44]Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands [45]Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States [46]National Institutes of Health, Baltimore, MD, United States [47]Estonian Genome Center, Insititute of Genomics, University of Tartu, Tartu, Estonia [48]European Genomic Institute for Diabetes, Institut Pasteur de Lille, Lille, France [49]University of Lille, Lille University Hospital, Lille, France [50]Unit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark [51]Nephrology Division, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States [52]Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, NC, United States [53]Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom [54]Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom [55]Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [56]Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, United States [57]Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany [58]Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany [59]Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden [60]Department of Population and Quantitative Health Sciences, Cleveland, OH, United States [61]Department of Mathematics and Statistics, St.Cloud State University, St.Cloud, MN, United States [62]Department of Clinical Chemistry, University of Tampere, Tampere, Finland [63]Finnish Cardiovascular Research Center, University of Tampere, Tampere, Finland [64]Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands [65]Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden [66]Kuopio Research Institute of Exercise Medicine, Kuopio, Finland [67]Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom [68]NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom [69]Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy [70]Biostatistics, Department of Medicine, Brigham and Women's Hospital, Harvard University, Boston, MA, United States [71]Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan [72]Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, United States [73]Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands [74]Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands [75]Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, United States [76]Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald and University of Greifswald, Greifswald, Germany [77]German Center for Cardiovascular Research, Greifswald, Germany [78]Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States [79]Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States [80]Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden [81]Department of Genetic Medicine, McKusick-Nathans Institute, Johns Hopkins University School of Medicine, Baltimore, MD, United States [82]Section of Cardiovascular Research, Baylor College of Medicine, Houston, TX, United States [83]Houston Methodist Debakey Heart and Vascular Center, Houston, TX, United States [84]Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, United States [85]Section on Genomic Pediatrics, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States [86]Centre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom [87]Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom [88]Data Science Unit, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore [89]Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands [90]Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka [91]Tropical Medicine Research Institute, University of the West Indies, Mona, Jamaica [92]Braun School of Public Health, Hadassah Medical Center, Hebrew University, Jerusalem, Israel [93]Section for Nutritional Research, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden [94]Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland [95]Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore [96]Khoo Teck Puat National University Children's Medical Institute, National University Health System, Singapore, Singapore [97]Department of Internal Medicine, University of Utah, Salt Lake City, UT, United States [98]Department of Genetic Medicine, Weill Cornell Medicine in Qatar, Doha, Qatar [99]Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, United States [100]Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark [101]Department of Environmental Medicine and Public Health, The Icahn School of Medicine at Mount Sinai, New York, NY, United States [102]Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore [103]Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, Singapore [104]Epidemiology, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States [105]Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany [106]Institute of Human Genetics, Technische Universität München, Munich, Germany [107]Psychiatry, VU Medisch Centrum, Amsterdam, Netherlands [108]Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany [109]Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, United States [110]Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, United States [111]Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, United States [112]Geriatrics Section, Department of Medicine, Boston University School of Medicine, Boston, MA, United States [113]German Center for Cardiovascular Research, Neuherberg, Germany [114]Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland [115]Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland [116]Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland [117]Division of Research, Kaiser Permanente of Northern California, Oakland, CA, United States [118]Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh, United Kingdom [119]German Research Center for Environmental Health, Helmholtz Zentrum München, Institute of Genetic Epidemiology, Neuherberg, Germany [120]Institute of Medical Informatics Biometry and Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany [121]Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore [122]Duke-National University of Singapore Medical School, Singapore, Singapore [123]Department of Laboratory Medicine and Pathology, Minneapolis, MN, United States [124]Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands [125]German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany [126]Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China [127]Jackson Heart Study Graduate Training Center, School of Public, Jackson State University, Jackson, MS, United States [128]Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States [129]Division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Pittsburgh, PA, United States [130]Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom [131]Broad Institute, Massachusetts Institute of Technology and Harvard University, Boston, MA, United States [132]Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden [133]Department of Nutrition, Harvard Chan School of Public Health, Boston, MA, United States [134]German Center for Diabetes Research, Neuherberg, Germany [135]Department of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany [136]Institute of Molecular and Clinical Ophthalmology, Basel, Switzerland [137]Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland [138]Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States [139]Celgene, Bristol Myers Squibb, Mississauga, ON, Canada [140]Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy [141]Division Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, University of Utrecht, Utrecht, Netherlands [142]Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany [143]National Institute on Aging, National Institutes of Health, Bethesda, MD, United States [144]Division of Cardiology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, United States [145]Faculty of Medicine, University of Iceland, Reykjavik, Iceland [146]Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands [147]Department of Epidemiology, University of Washington, Seattle, WA, United States [148]Department of Health Systems and Population Health, University of Washington, Seattle, WA, United States [149]Centre for Global Health, The Usher Institute, The University of Edinburgh, Edinburgh, United Kingdom [150]Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom [151]Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC, United States [152]Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom [153]College of Public Health, Dean's Office, University of Kentucky, Lexington, KY, United States [154]Division of Biostatistics, Population and Public Health Sciences, University of Southern California, Los Angeles, CA, United States
出处：
DOI： 10.3389/fgene.2023.1235337
ISSN：

关键词： educational attainment lipids cholesterol triglycerides genome-wide association study meta-analysis

摘要：
Introduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes. Methods: A two-stage genome-wide meta-analysis of low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglyceride (TG) levels was performed while accounting for gene-educational attainment interactions in up to 226,315 individuals from five population groups. We considered two educational attainment variables: "Some College" (yes/no, for any education beyond high school) and "Graduated College" (yes/no, for completing a 4-year college degree). Genome-wide significant (p < 5 × 10-8) and suggestive (p < 1 × 10-6) variants were identified in Stage 1 (in up to 108,784 individuals) through genome-wide analysis, and those variants were followed up in Stage 2 studies (in up to 117,531 individuals). Results: In combined analysis of Stages 1 and 2, we identified 18 novel lipid loci (nine for LDL, seven for HDL, and two for TG) by two degree-of-freedom (2 DF) joint tests of main and interaction effects. Four loci showed significant interaction with educational attainment. Two loci were significant only in cross-population analyses. Several loci include genes with known or suggested roles in adipose (FOXP1, MBOAT4, SKP2, STIM1, STX4), brain (BRI3, FILIP1, FOXP1, LINC00290, LMTK2, MBOAT4, MYO6, SENP6, SRGAP3, STIM1, TMEM167A, TMEM30A), and liver (BRI3, FOXP1) biology, highlighting the potential importance of brain-adipose-liver communication in the regulation of lipid metabolism. An investigation of the potential druggability of genes in identified loci resulted in five gene targets shown to interact with drugs approved by the Food and Drug Administration, including genes with roles in adipose and brain tissue. Discussion: Genome-wide interaction analysis of educational attainment identified novel lipid loci not previously detected by analyses limited to main genetic effects.Copyright © 2023 de las Fuentes, Schwander, Brown, Bentley, Winkler, Sung, Munroe, Miller, Aschard, Aslibekyan, Bartz, Bielak, Chai, Cheng, Dorajoo, Feitosa, Guo, Hartwig, Horimoto, Kolčić, Lim, Liu, Manning, Marten, Musani, Noordam, Padmanabhan, Rankinen, Richard, Ridker, Smith, Vojinovic, Zonderman, Alver, Boissel, Christensen, Freedman, Gao, Giulianini, Harris, He, Hsu, Kühnel, Laguzzi, Li, Lyytikäinen, Nolte, Poveda, Rauramaa, Riaz, Robino, Sofer, Takeuchi, Tayo, van der Most, Verweij, Ware, Weiss, Wen, Yanek, Zhan, Amin, Arking, Ballantyne, Boerwinkle, Brody, Broeckel, Campbell, Canouil, Chai, Ida Chen, Chen, Chitrala, Concas, de Faire, de Mutsert, de Silva, de Vries, Do, Faul, Fisher, Floyd, Forrester, Friedlander, Girotto, Gu, Hallmans, Heikkinen, Heng, Homuth, Hunt, Ikram, Jacobs, Kavousi, Khor, Kilpeläinen, Koh, Komulainen, Langefeld, Liang, Liu, Liu, Lohman, Mägi, Manichaikul, McKenzie, Meitinger, Milaneschi, Nauck, Nelson, O’Connell, Palmer, Pereira, Perls, Peters, Polašek, Raitakari, Rice, Rice, Rich, Sabanayagam, Schreiner, Shu, Sidney, Sims, Smith, Starr, Strauch, Tai, Taylor, Tsai, Uitterlinden, van Heemst, Waldenberger, Wang, Wei, Wilson, Xuan, Yao, Yu, Yuan, Zhao, Becker, Bonnefond, Bowden, Cooper, Deary, Divers, Esko, Franks, Froguel, Gieger, Jonas, Kato, Lakka, Leander, Lehtimäki, Magnusson, North, Ntalla, Penninx, Samani, Snieder, Spedicati, van der Harst, Völzke, Wagenknecht, Weir, Wojczynski, Wu, Zheng, Zhu, Bouchard, Chasman, Evans, Fox, Gudnason, Hayward, Horta, Kardia, Krieger, Mook-Kanamori, Peyser, Province, Psaty, Rudan, Sim, Smith, van Dam, van Duijn, Wong, Arnett, Rao, Gauderman, Liu, Morrison, Rotter and Fornage.

基金：
This project was largely supported by two grants from the U.S. National Heart, Lung, and Blood Institute (NHLBI), the National Institutes of Health, R01HL118305 and R01HL156991. This research was supported in part by the Intramural Research Program of the National Human Genome Research Institute, National Institutes of Health (AB). An NHLBI career development award (K25HL121091) enabled YS to play an important role on this project.
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 生物学
小类 | 3 区 遗传学
最新[2025]版：
大类 | 3 区 生物学
小类 | 3 区 遗传学
JCR分区：
出版当年[2021]版：
Q1 GENETICS & HEREDITY
最新[2023]版：
Q2 GENETICS & HEREDITY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St.Louis, MO, United States [2]Division of Biostatistics, Washington University School of Medicine, St.Louis, MO, United States
共同第一作者：
通讯作者：
通讯机构： [1]Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St.Louis, MO, United States [2]Division of Biostatistics, Washington University School of Medicine, St.Louis, MO, United States
推荐引用方式(GB/T 7714)：
Lisa de las Fuentes,Karen L. Schwander,Michael R. Brown,et al.Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci[J].FRONTIERS IN GENETICS.2023,14:1235337.doi:10.3389/fgene.2023.1235337.
APA：
Lisa de las Fuentes,Karen L. Schwander,Michael R. Brown,Amy R. Bentley,Thomas W. Winkler...&Myriam Fornage.(2023).Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci.FRONTIERS IN GENETICS,14,
MLA：
Lisa de las Fuentes,et al."Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci".FRONTIERS IN GENETICS 14.(2023):1235337

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