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Depression- and anxiety-associated disrupted brain structural networks revealed by probabilistic tractography in thyroid associated ophthalmopathy

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WOS体系：
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收录情况： ◇ SCIE ◇ SSCI

作者：
Luo Lihua[1] * ; Gao Lixin[1] ; Li Dongmei[2] ; Wen Hongwei[3] ;
机构： [1]Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050,China. [2]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, Beijing 100730, China. [3]Key Laboratory of Cognition and Personality (Ministry of Education), Faculty of Psychology, Southwest University, Chongqing 400715, China.
出处：
DOI： 10.1016/j.jad.2023.11.089
ISSN：

关键词： Thyroid associated ophthalmopathy Depression and anxiety Diffusion probabilistic tractography Brain structural networks Graph theory

摘要：
Patients with thyroid-associated opthalmopathy (TAO) have widespread white matter (WM) abnormalities in the emotional and cognitive functional regions. However, the topological representation of these WM abnormalities and the network-level structural aberrations underlying TAO and concomitant affective disorders are still unclear.We used probabilistic diffusion tractography and graph theory to investigate brain network topology in 37 active, 35 inactive TAO patients and 23 healthy controls. Then, we evaluated the partial correlations between network topological metrics and clinical parameters.For global topology, only active TAO patients exhibited significantly decreased global (Eglob) and local (Eloc) efficiency compared with controls, while no significant difference was observed between active and inactive TAO patients. For regional topology, we found a significantly decreased nodal efficiency in the left orbital superior frontal gyrus (ORBsup), medial orbital superior frontal gyrus (ORBsupmed), hippocampus and amygdala in active TAO patients compared with inactive ones. Intriguingly, Eglob, Eloc, and nodal efficiency of left ORBsup, ORBsupmed, olfactory cortex, gyrus rectus, hippocampus, right parahippocampal gyrus and amygdala had significantly positive correlations with anxiety/depression scores, bilateral exophthalmos and intraocular pressure in active TAO patients, while no significant correlation was observed in inactive TAO patients.No longitudinal follow-up.WM networks of TAO are characterized by decreased local specialization and global integration in the active phase, and decreased nodal efficiency highly related to anxiety and depression in the emotional and cognitive regions. Our findings provide new insight regarding the neurobiological mechanisms of TAO and contribute to the treatment of concomitant affective disorders.Copyright © 2023. Published by Elsevier B.V.

基金：
National Natural Science Foundation of China (32100902, 82071005); the Fundamental Research Funds for the Central Universities (SWU118065); the Research Foundation of Beijing Friendship Hospital, Capital Medical University (yyqdkt2018- 33); and the Special Fund of the Pediatric Medical Coordinated Development Center of Beijing Hospitals Authority, Beijing Municipal Hospital Management Center (grant number: XTCX201824).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 医学
小类 | 2 区 临床神经病学 2 区 精神病学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 临床神经病学 2 区 精神病学
JCR分区：
出版当年[2022]版：
Q1 CLINICAL NEUROLOGY Q1 PSYCHIATRY
最新[2023]版：
Q1 CLINICAL NEUROLOGY Q1 PSYCHIATRY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050,China.
通讯作者：
推荐引用方式(GB/T 7714)：
Luo Lihua,Gao Lixin,Li Dongmei,et al.Depression- and anxiety-associated disrupted brain structural networks revealed by probabilistic tractography in thyroid associated ophthalmopathy[J].JOURNAL OF AFFECTIVE DISORDERS.2024,347:515-525.doi:10.1016/j.jad.2023.11.089.
APA：
Luo Lihua,Gao Lixin,Li Dongmei&Wen Hongwei.(2024).Depression- and anxiety-associated disrupted brain structural networks revealed by probabilistic tractography in thyroid associated ophthalmopathy.JOURNAL OF AFFECTIVE DISORDERS,347,
MLA：
Luo Lihua,et al."Depression- and anxiety-associated disrupted brain structural networks revealed by probabilistic tractography in thyroid associated ophthalmopathy".JOURNAL OF AFFECTIVE DISORDERS 347.(2024):515-525

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