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Nanocatalytic theranostics with intracellular mutual promotion for ferroptosis and chemo-photothermal therapy

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收录情况： ◇ SCIE

作者：
Zhang Minyi[1] * ; Chen Ying[2] * ; Wang Qi[3] ; Li Chunlin[4] ; Yuan Chunping[1] ; Lu Jie[1] ; Luo Yu[1] ; Liu Xijian[1] ;
机构： [1]School of Chemistry and Chemical Engineering, Shanghai Engineering Technology Research Center for Pharmaceutical Intelligent Equipment, Shanghai Frontiers Science Research Center for Druggability of Cardiovascular Noncoding RNA, Institute for Frontier Medical Technology, Shanghai University of Engineering Science, Shanghai 201620, China. [2]Department of Radiation Oncology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, No.1111, Xianxia Road, Shanghai 200336, China. [3]Research Institute of Digital and Intelligent Orthopedics, Department of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, No. 2800 Gongwei Road, Huinan Town, Pudong, Shanghai 201399, China. [4]Trauma Center, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201620, China.
出处：
DOI： 10.1016/j.jcis.2023.12.006
ISSN：

关键词： GSH-depleting Metal sulfides Chemo-photothermal therapy Ferroptosis Co-catalyzers

摘要：
The reactive oxygen species (ROS) produced through the Fenton reaction, induces lipid peroxide (LPO), causing cellular structural damage and ultimately triggering ferroptosis. However, the generation of ROS in the tumor microenvironment (TME) is limited by the catalytic efficiency of the Fenton reaction. Herein, a novel hollow mesoporous silica nanoparticle (HMSN) combined with multi-metal sulfide-doped mesoporous silica nanocatalyzers (NCs) was developed, namely MxSy-HMSN NCs (M represents Cu Mn and Fe, S denotes sulfur). The MxSy-HMSN can dramatically enhanced the ferroptosis by: (1) facilitating the conversion of H2O2 to ·OH through Fenton or Fenton-like reactions through co-catalysis; (2) weakening ROS scavenging systems by depleting the over expressed glutathione (GSH) in TME; (3) providing exceptional photothermal therapy to augment ferroptosis. The MxSy-HMSN can also act as smart cargos for anticancer drug-doxorubicin (DOX). The release of DOX is responsive to GSH/pH/Near-infrared Light (NIR) irradiation at the tumor lesion, significantly improving therapeutic outcomes while minimizing side effects. Additionally, the MxSy-HMSN has demonstrated excellent magnetic resonance imaging (MRI) potential. This smart MxSy-HMSN offer a synergetic approach combining ferroptosis with chemo-photothermal therapy and magnetic resonance imaging (MRI) diagnose, which could be an informative guideline for the design of future NCs.Copyright © 2023 Elsevier Inc. All rights reserved.

基金：
This work was financially supported by the National Natural Science Foundation of China (Nos. 52272280, 21978165, 92156020), Class III Peak Discipline of Shanghai-Materials Science and Engineering (High- Energy Beam Intelligent Processing and Green Manufacturing), Changning District Committee of Science and Technology (CNKW2022Y07), and Beijing Medical Award Foundation (BMAF) (YXJL-2023-0369-0014), and the Science and Technology Commission of Shanghai (No. 20DZ2255900).
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外文
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 化学
小类 | 2 区 物理化学
最新[2025]版：
大类 | 1 区 化学
小类 | 2 区 物理化学
JCR分区：
出版当年[2022]版：
Q1 CHEMISTRY, PHYSICAL
最新[2023]版：
Q1 CHEMISTRY, PHYSICAL

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]School of Chemistry and Chemical Engineering, Shanghai Engineering Technology Research Center for Pharmaceutical Intelligent Equipment, Shanghai Frontiers Science Research Center for Druggability of Cardiovascular Noncoding RNA, Institute for Frontier Medical Technology, Shanghai University of Engineering Science, Shanghai 201620, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Minyi,Chen Ying,Wang Qi,et al.Nanocatalytic theranostics with intracellular mutual promotion for ferroptosis and chemo-photothermal therapy[J].JOURNAL OF COLLOID AND INTERFACE SCIENCE.2024,657:619-631.doi:10.1016/j.jcis.2023.12.006.
APA：
Zhang Minyi,Chen Ying,Wang Qi,Li Chunlin,Yuan Chunping...&Liu Xijian.(2024).Nanocatalytic theranostics with intracellular mutual promotion for ferroptosis and chemo-photothermal therapy.JOURNAL OF COLLOID AND INTERFACE SCIENCE,657,
MLA：
Zhang Minyi,et al."Nanocatalytic theranostics with intracellular mutual promotion for ferroptosis and chemo-photothermal therapy".JOURNAL OF COLLOID AND INTERFACE SCIENCE 657.(2024):619-631

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