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A new risk factor for coronary artery disease can be detected by an ApoA1 mAb-based assay

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收录情况： ◇ SCIE

作者：
Ding Hui[1] * ; Wang Yin[2] * ; Zhang Yan[3] * ; Zhou Lida[1] ; Wang Dong[2] ; Lv Liangjie[3] ; Wan Qianli[2] ; Tong Minghong[1] ; Deng Chenxia[1] ; Xu Huihong[1] ; Zu Bailing[1] ; Zhang Jie[3,*2] ; Qiu Zhaohui[2,*1] ; Sheng Huiming[1,*1] ;
机构： [1]Department of Laboratory Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China. [2]Department of Cardiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China. [3]Shanghai R&D Center, DiaSys Diagnostic Systems (Shanghai) Co., Ltd., Shanghai 201318, China.
出处：
DOI： 10.1016/j.cca.2023.117700
ISSN：

关键词： Coronary artery disease High-density lipoprotein (HDL) subclass Apolipoprotein A1 (ApoA1) Clinical diagnosis Risk assessment

摘要：
This study aimed to find coronary artery disease (CAD) related apolipoprotein A1 (ApoA1) monoclonal antibody (mAb) and to evaluate the diagnostic value of the assay based on it.Patients with CAD diagnosed by coronary angiography (disease group, n = 180) and healthy subjects (control group, n = 199) were recruited. The correlation between methods and CAD were evaluated by Spearman's rank correlation coefficients. Receiver operating characteristic (ROC) curve analysis was used to evaluate the auxiliary diagnostic value of methods for CAD. Odds ratios (ORs) of the test results in CAD were estimated using logistic regression analysis.Measurements from an ApoA1 mAb were found significantly positively correlated with CAD (r = 0.243, P < 0.01), unlike the measurements from the ApoA1 pAb were negatively correlated with CAD (r = -0.341, P < 0.001). The areas under the ROC curve of the ApoA1 mAb and pAb measurements were 0.704 and 0.563, respectively, in patients with normal HDL-C levels. ApoA1 values from the mAb assay had a significant positive impact on CAD risk.An ApoA1 mAb-based assay can distinguish a high-density lipoprotein (HDL) subclass positively related to CAD, which can be used to improve and reappraise CAD risk assessment.Copyright © 2023 Elsevier B.V. All rights reserved.

基金：
This work was supported by the Science and Technology Commission of Shanghai Municipality, China; the grant numbers are 17441906100, 18441906500, 19441915100 and 23S31905800.
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外文
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 3 区 医学
小类 | 3 区 医学实验技术
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 医学实验技术
JCR分区：
出版当年[2022]版：
Q1 MEDICAL LABORATORY TECHNOLOGY
最新[2023]版：
Q2 MEDICAL LABORATORY TECHNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Laboratory Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Laboratory Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China. [2]Department of Cardiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China. [3]Shanghai R&D Center, DiaSys Diagnostic Systems (Shanghai) Co., Ltd., Shanghai 201318, China. [*1]No. 1111, Xianxia Road, Shanghai, China [*2]Shanghai International Medical Zone (SIMZ), No. 9, Lane 222, Guangdan Road, Shanghai, China
推荐引用方式(GB/T 7714)：
Ding Hui,Wang Yin,Zhang Yan,et al.A new risk factor for coronary artery disease can be detected by an ApoA1 mAb-based assay[J].CLINICA CHIMICA ACTA.2024,552:117700.doi:10.1016/j.cca.2023.117700.
APA：
Ding Hui,Wang Yin,Zhang Yan,Zhou Lida,Wang Dong...&Sheng Huiming.(2024).A new risk factor for coronary artery disease can be detected by an ApoA1 mAb-based assay.CLINICA CHIMICA ACTA,552,
MLA：
Ding Hui,et al."A new risk factor for coronary artery disease can be detected by an ApoA1 mAb-based assay".CLINICA CHIMICA ACTA 552.(2024):117700

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