机构：[1]Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia.[2]Department of Surgery (Ophthalmology), The University of Melbourne, Melbourne, Victoria, Australia.[3]Faculty of Medicine, Nursing and Health Science, Monash University, Clayton, Victoria, Australia.[4]Department of Oncology, University of Cambridge, Cambridge, UK.[5]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[6]Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.[7]Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.广东省人民医院[8]School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong.[9]Research Centre for SHARP Vision, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
This study aimed to investigate the association between quantitative retinal vascular measurements and the risk of all-cause and premature mortality.In this population-based cohort study using the UK Biobank data, we employed the Retina-based Microvascular Health Assessment System to assess fundus images for image quality and extracted 392 retinal vascular measurements per fundus image. These measurements encompass six categories of vascular features: caliber, density, length, tortuosity, branching angle, and complexity. Univariate Cox regression models were used to identify potential indicators of mortality risk using data on all-cause and premature mortality from death registries. Multivariate Cox regression models were then used to test these associations while controlling for confounding factors.The final analysis included 66,415 participants. After adjusting for demographic, health, and lifestyle factors and genetic risk score, 18 and 10 retinal vascular measurements were significantly associated with all-cause mortality and premature mortality, respectively. In the fully adjusted model, the following measurements of different vascular features were significantly associated with all-cause mortality and premature mortality: arterial bifurcation density (branching angle), number of arterial segments (complexity), interquartile range and median absolute deviation of arterial curve angle (tortuosity), mean and median values of mean pixel widths of all arterial segments in each image (caliber), skeleton density of arteries in macular area (density), and minimum venular arc length (length).The study revealed 18 retinal vascular measurements significantly associated with all-cause mortality and 10 associated with premature mortality. Those identified parameters should be further studied for biological mechanisms connecting them to increased mortality risk.This study identifies retinal biomarkers for increased mortality risk and provides novel targets for investigating the underlying biological mechanisms.
基金：
This project received grant funding from the
AustralianGovernment: the NationalCriticalResearch
Infrastructure Initiative, Medical Research Future
Fund (MRFAI00035) and the NHMRC Investigator
Grant (APP1175405). The contents of the published
material are solely the responsibility of the Administering
Institution, a participating institution or individual
authors and do not reflect the views of the NHMRC.
This work was supported by grants from the Funda-mental Research Funds of the State Key Laboratory
of Ophthalmology, Project of Investigation on
Health Status of Employees in Financial Industry in
Guangzhou, China (Z012014075); and Global STEM
Professorship Scheme (P0046113).
第一作者机构：[1]Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia.[2]Department of Surgery (Ophthalmology), The University of Melbourne, Melbourne, Victoria, Australia.
通讯作者：
通讯机构：[1]Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia.[2]Department of Surgery (Ophthalmology), The University of Melbourne, Melbourne, Victoria, Australia.[8]School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong.[9]Research Centre for SHARP Vision, The Hong Kong Polytechnic University, Kowloon, Hong Kong.[*1]11 Yuk Choi Rd Hung Hom, KLN, Hong Kong.[*2]School of Optometry, The Hong Kong Polytechnic University, 11 Yuk Choi Road, Hung Hom, KLN, Hong Kong SAR
推荐引用方式(GB/T 7714)：
Yusufu Mayinuer,Chen Yutong,Dayimu Alimu,et al.Retinal Vascular Measurements and Mortality Risk: Evidence From the UK Biobank Study[J].TRANSLATIONAL VISION SCIENCE & TECHNOLOGY.2024,13(1):2.doi:10.1167/tvst.13.1.2.
APA：
Yusufu Mayinuer,Chen Yutong,Dayimu Alimu,Bulloch Gabriella,Jin Shanshan...&He Mingguang.(2024).Retinal Vascular Measurements and Mortality Risk: Evidence From the UK Biobank Study.TRANSLATIONAL VISION SCIENCE & TECHNOLOGY,13,(1)
MLA：
Yusufu Mayinuer,et al."Retinal Vascular Measurements and Mortality Risk: Evidence From the UK Biobank Study".TRANSLATIONAL VISION SCIENCE & TECHNOLOGY 13..1(2024):2
