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Diabetic Retinopathy and Brain Structure, Cognition Function, and Dementia: A Bidirectional Mendelian Randomization Study

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收录情况： ◇ SCIE

作者：

机构： [1]Beijing Tongren Hospital, Capital Medical University, Beijing, China. [2]Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

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关键词： lzheimer’s disease cerebral cortex cognitive function dementia diabetic retinopathy Mendelian randomization vascular dementia

摘要：

Accumulating evidence has demonstrated that hyperglycemia is a possible risk factor for mild cognitive impairment or Alzheimer's disease. Diabetic retinopathy (DR) has been identified as a risk factor for dementia in patients with diabetes.This study aimed to investigate the causal relationships between DR and brain structure, cognitive function, and dementia.We performed bidirectional two-sample Mendelian randomization for DR, brain structure, cognitive function, and dementia using the inverse-variance weighted method.Inverse-variance weighted analysis showed the association of DR with vascular dementia (OR = 1.68, 95% CI: 1.01-2.82), and dementia was significantly associated with the increased risk of non-proliferative DR (NPDR) (OR = 1.76, 95% CI: 1.04-2.98). Furthermore, better cognitive performance was significantly associated with a reduced risk of NPDR (OR = 0.85, 95% CI: 0.74-0.98). No association was observed between DR and brain structure.These findings suggest that the association of DR with vascular dementia. The reciprocal effect of cognitive performance and dementia on NPDR risk highlights the potential benefits of dementia prevention for reducing the burden of DR.

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中科院(CAS)分区：

出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区神经科学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区神经科学

JCR分区：

出版当年[2022]版：

Q2 NEUROSCIENCES

最新[2023]版：

Q2 NEUROSCIENCES

影响因子： 3.4 最新[2023版] 4.2 最新五年平均 4 出版当年[2022版] 4.9 出版当年五年平均 4.16 出版前一年[2021版] 3.4 出版后一年[2023版]

第一作者：

第一作者机构： [1]Beijing Tongren Hospital, Capital Medical University, Beijing, China.

通讯作者：

通讯机构： [2]Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [*1]Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, China.

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