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Transcription factor CEBPB mediates intracranial aneurysm rupture by inflammatory and immune response

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机构： [1]Department of Interventional Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. [2]Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. [3]Department of Neurosurgery, Beijing Tongren Hospital, Capital Medial University, Beijing, China. [4]Department of Neurointerventional Surgery, Binzhou Medical University Hospital, Binzhou, China.

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关键词： bioinformatics inflammation and immune response intracranial aneurysm rupture transcription factors

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Genetic factors play a major part in mediating intracranial aneurysm (IA) rupture. However, research on the role of transcription factors (TFs) in IA rupture is rare.Bioinformatics analysis was performed to explore the TFs and related functional pathways involved in IA rupture.A total of 63 differentially expressed transcription factors (DETFs) were obtained. Significantly enriched biological processes of these DETFs were related to regulation of myeloid leukocyte differentiation. The top 10 DETFs were screened based on the MCC algorithm from the protein-protein interaction network. After screening and validation, it was finally determined that CEBPB may be the hub gene for aneurysm rupture. The GSEA results of CEBPB were mainly associated with the inflammatory response, which was also verified by the experimental model of cellular inflammation in vitro.The inflammatory and immune response may be closely associated with aneurysm rupture. CEBPB may be the hub gene for aneurysm rupture and may have diagnostic value. Therefore, CEBPB may serve as the diagnostic signature for RIAs and a potential target for intervention.© 2024 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.

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出版当年[2023]版：

大类 | 1 区医学

小类 | 2 区神经科学 2 区药学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区药学 3 区神经科学

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出版当年[2022]版：

Q1 NEUROSCIENCES Q1 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q1 NEUROSCIENCES Q1 PHARMACOLOGY & PHARMACY

影响因子： 4.8 最新[2023版] 5.9 最新五年平均 5.5 出版当年[2022版] 6.2 出版当年五年平均 7.035 出版前一年[2021版] 4.8 出版后一年[2023版]

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第一作者机构： [1]Department of Interventional Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

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