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Low-dose polystyrene microplastics exposure impairs fertility in male mice with high-fat diet-induced obesity by affecting prostate function

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收录情况： ◇ SCIE

作者：
Gao Dajun[1] * ; Zhang Caoxu[2] * ; Guo Huaqi[3] ; Xu Huan[4] ; Liu Hui[5] ; Wang Zhong[6] ; Xu Bin[7] ; Gang Wei[8] ;
机构： [1]Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China. [2]Department of Molecular Diagnostics, The Core Laboratory in Medical Center of Clinical Research, Department of Endocrinology, Shanghai Ninth People's Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China. [3]Department of Respiratory Medicine, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, 639 Zhizaoju Lu, Shanghai, 200011, China. [4]Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China. [5]Bengbu Medical College Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Department of Biochemistry and Molecular Biology, School of Laboratory Medicine, Bengbu Medical College, Bengbu, 233030, China. [6]Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China. [7]Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China. [8]Beijing Key Laboratory of Diabetes Research and Care, Department of Endocrinology, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, 100005, China, Department of Endocrinology and Metabolism, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China
出处：
DOI： 10.1016/j.envpol.2024.123567
ISSN：

关键词： Microplastics Polystyrene Obesity Reproduction Mammals

摘要：
The harmful effects of microplastics (MPs) on male fertility are receiving more and more attention. However, the impact of low-dose MPs exposure on the reproductive function of male mice is still unclear. In this study, we exposed male mice to low-dose MPs (25-30 μg/kg body weight/day) or low-dose MPs combined with high-fat diet (HFD) feeding. Our results showed that low-dose MPs exposure or HFD feeding significantly reduced sperm quality and the number of offspring born, while low-dose MPs exposure combined with HFD feeding further enhanced the above effects. The combination of low-dose MPs exposure and HFD feeding resulted in a notable elevation of inflammatory level within the prostate of mice and induced apoptosis of prostate epithelium and a decrease in nutrients (zinc, citrate) in seminal plasma fluid. Our findings in this study could provide valuable clues for better understanding the influence of low-dose MPs exposure on the reproductive system under metabolic disorders and facilitate the development of the prevention of reproductive toxicity caused by MPs exposure.Copyright © 2024. Published by Elsevier Ltd.

基金：
This work was supported by the Fundamental Research Funds for the Central Universities (project number: YG2021QN75); National Natural Science Foundation of China (82203550, HX; 82000804 and 82370547, GW; 81970656 and 81900687, ZW); Shanghai Municipal Natural Science Foundation (21ZR1437800, HX), supported by Shanghai Scientific.
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外文
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出版当年[2023]版：
大类 | 2 区 环境科学与生态学
小类 | 2 区 环境科学
最新[2023]版：
大类 | 2 区 环境科学与生态学
小类 | 2 区 环境科学
JCR分区：
出版当年[2022]版：
Q1 ENVIRONMENTAL SCIENCES
最新[2023]版：
Q1 ENVIRONMENTAL SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China.
共同第一作者：
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推荐引用方式(GB/T 7714)：
Gao Dajun,Zhang Caoxu,Guo Huaqi,et al.Low-dose polystyrene microplastics exposure impairs fertility in male mice with high-fat diet-induced obesity by affecting prostate function[J].ENVIRONMENTAL POLLUTION.2024,346:123567.doi:10.1016/j.envpol.2024.123567.
APA：
Gao Dajun,Zhang Caoxu,Guo Huaqi,Xu Huan,Liu Hui...&Gang Wei.(2024).Low-dose polystyrene microplastics exposure impairs fertility in male mice with high-fat diet-induced obesity by affecting prostate function.ENVIRONMENTAL POLLUTION,346,
MLA：
Gao Dajun,et al."Low-dose polystyrene microplastics exposure impairs fertility in male mice with high-fat diet-induced obesity by affecting prostate function".ENVIRONMENTAL POLLUTION 346.(2024):123567

相关文献

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