机构：[1]Shanghai University of Traditional Chinese Medicine, Shanghai, China[2]Department of Medical Records and Statistics, Shanghai PuDong Guangming Hospital of Traditional Chinese Medicine, Shanghai, China[3]Department of Emergency, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
We aimed to investigate the association of iron metabolism-related parameters with 60-day mortality in critically ill patients with sepsis.Serum or urine concentrations of iron metabolism-related parameters on intensive care unit admission were measured in a prospective cohort of 133 eligible patients with sepsis according to the Sepsis-3 criteria, and these values were compared between survivors and nonsurvivors, categorized according to their 60-day survival status. Cox regression analyses were performed to examine the association between iron parameters and 60-day mortality. Kaplan-Meier methods were used to illustrate the differences in survival between different iron parameters.Of the 133 patients included in the study, 61 (45.8%) had died by day 60. After adjusting for confounding variables, higher concentrations of serum iron (cut-off 9.5 μmol/mL) and higher concentrations of urine neutrophil gelatinase-associated lipocalin (uNGAL; cut-off 169.3 ng/mL) were associated with a significantly greater risk of death in the Cox regression analysis. These two biomarkers combined with Sequential Organ Failure Assessment (SOFA) scores increased the area under the receiver operating characteristic (AUROC) curve to 0.85.These findings suggest that higher concentrations of serum iron and uNGAL are each associated with higher 60-day mortality, and they add significant accuracy to this prediction in combination with SOFA. Abbreviations: uNGAL: urine neutrophil gelatinase-associated lipocalin; ICU: intensive care unit; SOFA: Sequential Organ Failure Assessment; APACHE II: the Acute Physiology and Chronic Health Evaluation II; ELISA: enzyme-linked immunosorbent assay; HR: hazard ratio; CIs: confidence intervals; WBC: white blood cell; TBIL: total bilirubin.
基金：
This work was supported by the Training Program for
Subject Leaders of Shanghai Pudong New District Municipal Health Bureau (grant number PWRd2016-08); and
the Shanghai Pudong New Area Science and Technology
Development Fund (grant number PKJ2019-Y26).
第一作者机构：[1]Shanghai University of Traditional Chinese Medicine, Shanghai, China
共同第一作者：
通讯作者：
通讯机构：[1]Shanghai University of Traditional Chinese Medicine, Shanghai, China[3]Department of Emergency, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
推荐引用方式(GB/T 7714)：
Zhao Rui,Liu Jiang-Hua,Qiu Ze-Liang.Value of serum iron and urine neutrophil gelatinase-associated lipocalin in predicting the mortality of critically ill patients with sepsis[J].CLINICAL AND INVESTIGATIVE MEDICINE.2024,47(1):4-12.doi:10.3138/cim-2024-2672.
APA：
Zhao Rui,Liu Jiang-Hua&Qiu Ze-Liang.(2024).Value of serum iron and urine neutrophil gelatinase-associated lipocalin in predicting the mortality of critically ill patients with sepsis.CLINICAL AND INVESTIGATIVE MEDICINE,47,(1)
MLA：
Zhao Rui,et al."Value of serum iron and urine neutrophil gelatinase-associated lipocalin in predicting the mortality of critically ill patients with sepsis".CLINICAL AND INVESTIGATIVE MEDICINE 47..1(2024):4-12
