Background: The neonatal congenital heart disease (NCHD) screening program has advanced in China. However, there are still some missed cases after discharge from maternity hospitals. Moreover, parents' cognitive level and compliance with congenital heart disease (CHD) management are limited. The current disease reporting system, which relies on medical personnel, encounters issues with data omission and misreporting, exacerbated by the manual follow-up process's inefficiency. Involving parents in NCHD management mitigates challenges arising from population mobility, deepens parents' comprehension of the disease, and promotes active data input, ultimately enhancing health management efficiency. Methods: We performed the key technologies, design, and architecture of the developed platform. It explores the applications of Mobile Health (M -Health) based on big data technology, representing an innovative approach to monitoring CHD that emphasizes the integration of advanced technologies such as data integration, online consultation, message reminders, and parental involvement. A feasibility assessment was conducted, involving interviews with medical staff, to evaluate the practicality and effectiveness of the system. Additionally, a preliminary analysis of platform usage was undertaken. Results: The platform demonstrated successful integration across the entire CHD management spectrum, including Parent Registration, Screening Phase, Diagnosis Phase, and Treatment Phase. It consists of a mobile APP and a back -end data management system. Parents input information on the platform, which is uploaded to the system. Then, the back -end data management system monitors the case course and provides regular reminders for the treatment and valuable related knowledge for CHD. Based on feedback from medical staff, valuable suggestions for platform enhancement were identified. A total of 891 infants from June 1, 2023, to August 31, 2023, were enrolled at two hospitals in China. Conclusions: This big data management platform sets a commendable example for the comprehensive management of NCHD. Continuous improvement in technological proficiency and security safeguards will likely enhance the platform's widespread and profound impact in future clinical practices. Timely feedback and adjustments during usage are crucial to ensuring the platform's effectiveness and adaptability, thereby guaranteeing the realization of the intended design effectiveness.