BackgroundThe current study presents the effort of a global collaborative group to review the management and outcomes of malignant tumors of the skull base worldwide.Patients and methodsA total of 28 institutions contributed data on 3061 patients. Analysis evaluated clinical variables, survival outcomes, and multivariable factors associated with outcomes.ResultsThe median age was 56 years (IQR 44-67). The open surgical approach was used in 55% (n = 1680) of cases, endoscopic resection was performed in 36% (n = 1087), and the combined approach in 9.6% (n = 294). With a median follow-up of 7.1 years, the 5-year OS DSS and RFS were 65%, 71.7% and 53%, respectively. On multivariable analysis, older age, comorbidities, histology, dural/intracranial involvement, positive margins, advanced stage, and primary site were independent prognostic factors for OS, DSS, and RFS. Adjuvant RT was a protective prognostic factor.ConclusionThe progress across various disciplines may have contributed to improved OS and DSS in this study compared to previous reports.
基金:
National Institutes of Health [P30 CA008748]; NIH/NCI Cancer Center Support Grant
第一作者机构:[1]Mem Sloan Kettering Canc Ctr, Dept Surg, 1275 York Ave, New York, NY 10065 USA[*1]Department of Surgery,Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA.
共同第一作者:
通讯作者:
通讯机构:[1]Mem Sloan Kettering Canc Ctr, Dept Surg, 1275 York Ave, New York, NY 10065 USA[*1]Department of Surgery,Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA.
推荐引用方式(GB/T 7714):
Shah Jatin P.,Levyn Helena,Valero Cristina,et al.Skull base surgery for malignant tumors: The 2nd international collaborative study (1995-2015)[J].HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK.2024,46(11):2762-2775.doi:10.1002/hed.27746.
APA:
Shah, Jatin P.,Levyn, Helena,Valero, Cristina,Adilbay, Dauren,Eagan, Alana...&Hanna, Ehab.(2024).Skull base surgery for malignant tumors: The 2nd international collaborative study (1995-2015).HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK,46,(11)
MLA:
Shah, Jatin P.,et al."Skull base surgery for malignant tumors: The 2nd international collaborative study (1995-2015)".HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 46..11(2024):2762-2775