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Skull base surgery for malignant tumors: The 2nd international collaborative study (1995-2015)

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机构: [1]Mem Sloan Kettering Canc Ctr, Dept Surg, 1275 York Ave, New York, NY 10065 USA [2]Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY USA [3]Tata Mem Hosp, Head & Neck Surg Oncol, Mumbai, India [4]Univ Insubria, Dept Otorhinolaryngol, Varese, Italy [5]Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China [6]Univ Brescia, Unit Otorhinolaryngol Head & Neck Surg, Spedali Civili BS Piazzale Spedali Civili, Brescia, Italy [7]Princess Alexandra Hosp, Dept Head & Neck Oncol, Woolloongabba, Qld, Australia [8]AC Camargo, Head & Neck Reference Ctr, Sao Paulo, Brazil [9]ICESP, Head & Neck Serv, Sao Paulo, Brazil [10]Univ Nicosia, Med Sch, Nicosia, Cyprus [11]Univ Hlth Network, Dept Otolaryngol Head & Neck Surg, Toronto, ON, Canada [12]Hispital Lariboisiere APHP, Skull Base Ctr, ENT Dept, Paris, France [13]Univ Milan, Unit Otorhinolaryngol Maxillofacial & Thyroid Surg, Milan, Italy [14]12 Octubre Univ Hosp, Oral & Maxillofacial Dept, Madrid, Spain [15]Atilim Univ, Fac Med, Dept Otolaryngol Head & Neck Surg, Med Int Ankara, Ankara, Turkiye [16]Amrita Inst Med Sci, Dept Head & Neck Surg & Oncol, Kochi, India [17]Sydney Ear Nose & Throat Clin, Darlinghurst, NSW, Australia [18]Vrije Univ Amsterdam, Otolaryngol Head & Neck Surg, Amsterdam Univ Med Ctr, Amsterdam, Netherlands [19]Hosp Italiano Buenos Aires, Dept Head & Neck Surg, Buenos Aires, Argentina [20]Kobe Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Kobe, Japan [21]Imperial Coll Healthcare NHS Trust, Charing Cross Hosp, ENT Dept, London, England [22]Aerosp Ctr Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100039, Peoples R China [23]Med Univ South Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC USA [24]Inst Nacl Canc, Dept Head & Neck Surg, Rio De Janeiro, Brazil [25]Univ Miami, Dept Otolaryngol, Miami, FL USA [26]Univ Hosp Birmingham, Dept Otolaryngol Head & Neck Surg, Birmingham, W Midlands, England [27]Greater Poland Canc Ctr, Dept Head & Neck Surg, PL-61866 Poznan, Poland [28]Yonsei Univ Hlth Syst, Dept ENT, Seoul, South Korea [29]MD Anderson Canc Ctr, Dept Head & Neck Surg, Houston, TX 77030 USA [30]MD Anderson Canc Ctr, Dept Neurosurg, Houston, TX USA
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关键词: global collaboration multimodality treatment prognostic factors skull base tumors survival outcomes

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BackgroundThe current study presents the effort of a global collaborative group to review the management and outcomes of malignant tumors of the skull base worldwide.Patients and methodsA total of 28 institutions contributed data on 3061 patients. Analysis evaluated clinical variables, survival outcomes, and multivariable factors associated with outcomes.ResultsThe median age was 56 years (IQR 44-67). The open surgical approach was used in 55% (n = 1680) of cases, endoscopic resection was performed in 36% (n = 1087), and the combined approach in 9.6% (n = 294). With a median follow-up of 7.1 years, the 5-year OS DSS and RFS were 65%, 71.7% and 53%, respectively. On multivariable analysis, older age, comorbidities, histology, dural/intracranial involvement, positive margins, advanced stage, and primary site were independent prognostic factors for OS, DSS, and RFS. Adjuvant RT was a protective prognostic factor.ConclusionThe progress across various disciplines may have contributed to improved OS and DSS in this study compared to previous reports.

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出版当年[2023]版:
大类 | 3 区 医学
小类 | 3 区 耳鼻喉科学 3 区 外科
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 耳鼻喉科学 3 区 外科
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出版当年[2022]版:
Q1 OTORHINOLARYNGOLOGY Q2 SURGERY
最新[2023]版:
Q1 OTORHINOLARYNGOLOGY Q1 SURGERY Q2 SURGERY

影响因子: 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

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第一作者机构: [1]Mem Sloan Kettering Canc Ctr, Dept Surg, 1275 York Ave, New York, NY 10065 USA [*1]Department of Surgery,Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA.
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通讯作者:
通讯机构: [1]Mem Sloan Kettering Canc Ctr, Dept Surg, 1275 York Ave, New York, NY 10065 USA [*1]Department of Surgery,Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA.
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