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Efficacy and Safety of Surgical Peripheral Iridectomy, Goniosynechialysis, and Goniotomy for Advanced Primary Angle-closure Glaucoma without Cataract: One-year Results of a Multicenter Study

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收录情况： ◇ SCIE

作者：
Gao Xinbo[1] * ; Lin Fengbin[1] * ; Lu Ping[2] * ; Xie Lin[3] ; Tang Li[4] ; Zhu Xiaomin[3] ; Zhang Yao[4] ; Lv Aiguo[2] ; Tang Guangxian[5] ; Zhang Hengli[5] ; Yan Xiaowei[5] ; Song Yunhe[1] ; Xu Jiangang[1] ; Huang Jingjing[1] ; Zhang Yingzhe[1] ; Hu Kun[1] ; Peng Yuying[1] ; Wang Zhenyu[1] ; Li Xiaoyan[2] ; Chen Weirong[1] ; Wang Ningli[6] ; Barton Keith[7] ; Park Ki Ho[8] ; Aung Tin[9] ; Weinreb Robert N[10] ; Lam Dennis S C[11] ; Fan Sujie[3,*3] ; Tham Clement C[12,*2] ; Zhang Xiulan[1,*1] ;
机构： [1]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, China. [2]Handan City Eye Hospital (The Third Hospital of Handan), Handan 056001, China. [3]Department of Ophthalmology, the Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, China. [4]Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu, Sichuan Province 610041, China. [5]Department of Ophthalmology, Shijiazhuang People's Hospital, Hebei Province, 050000, China. [6]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [7]NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, UCL Institute of Ophthalmology, London, UK. [8]Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea. [9]Singapore Eye Research Institute, Singapore National Eye Center, Singapore. [10]Hamilton Glaucoma Center, Viterbi Family Department of Ophthalmology, and Shiley Eye Institute, University of California San Diego, CA, USA. [11]International Eye Research Institute of The Chinese University of Hong Kong (Shenzhen), Shenzhen, China. [12]Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong Special Administrative Region, China.
出处：
DOI： 10.1097/IJG.0000000000002443
ISSN：

关键词： angle-closure glaucoma surgical peripheral iridectomy minimally invasive glaucoma surgery goniosynechialysis goniotomy

摘要：
The combination of surgical peripheral iridectomy, goniosynechialysis, and goniotomy is a safe and effective surgical approach for advanced primary angle-closure glaucoma without cataract.To evaluate the efficacy and safety of surgical peripheral iridectomy (SPI), goniosynechialysis (GSL), and goniotomy (GT) in advanced primary angle-closure glaucoma (PACG) eyes without cataract.A prospective multicenter observational study was performed for patients who underwent combined SPI, GSL, and GT for advanced PACG without cataract. Patients were assessed before and after the operation. Complete success was defined as achieving intraocular pressure (IOP) between 6-18 mm Hg with at least a 20% reduction compared to baseline, without the use of ocular hypotensive medications or reoperation. Qualified success adopted the same criteria but allowed medication use. Factors associated with surgical success were analyzed using logistic regression.A total of 61 eyes of 50 advanced PACG were included. All participants completed 12 months of follow-up. Thirty-six eyes (59.0%) achieved complete success, and 56 eyes (91.8%) achieved qualified success. Preoperative and postsurgical at 12 months mean IOPs were 29.7±7.7 and 16.1±4.8 mm Hg, respectively. The average number of ocular hypotensive medications decreased from 1.9 to 0.9 over 12 months. The primary complications included IOP spike (n=9), hyphema (n=7), and shallow anterior chamber (n=3). Regression analysis indicated that older age (odds ratio [OR]=1.09; P=0.043) was positively associated with complete success, while a mixed angle closure mechanism (OR=0.17; P=0.036) reduced success rate.The combination of SPI, GSL, and GT is a safe and effective surgical approach for advanced PACG without cataract. It has great potential as a first-line treatment option for these patients.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

基金：
This research is supported by the National Key R&D Program of China (2022YFC2502800), National Natural Science Foundation of China (81670860), and in part, funded by the Science and Technology Program of Sichuan Province (2020YJ0289)
语种：
外文
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 4 区 医学
小类 | 4 区 眼科学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 眼科学
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出版当年[2022]版：
Q3 OPHTHALMOLOGY
最新[2023]版：
Q2 OPHTHALMOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, China.
共同第一作者：
通讯作者：
通讯机构： [1]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, China. [3]Department of Ophthalmology, the Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, China. [12]Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong Special Administrative Region, China. [*1]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, No.7 Jinsui Road, Guangzhou 510060, China [*2]Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong Special Administrative Region, China [*3]Handan City Eye Hospital (The Third Hospital of Handan), Handan 056001, China
推荐引用方式(GB/T 7714)：
Gao Xinbo,Lin Fengbin,Lu Ping,et al.Efficacy and Safety of Surgical Peripheral Iridectomy, Goniosynechialysis, and Goniotomy for Advanced Primary Angle-closure Glaucoma without Cataract: One-year Results of a Multicenter Study[J].Journal Of Glaucoma.2024,33(9):632-639.doi:10.1097/IJG.0000000000002443.
APA：
Gao Xinbo,Lin Fengbin,Lu Ping,Xie Lin,Tang Li...&Zhang Xiulan.(2024).Efficacy and Safety of Surgical Peripheral Iridectomy, Goniosynechialysis, and Goniotomy for Advanced Primary Angle-closure Glaucoma without Cataract: One-year Results of a Multicenter Study.Journal Of Glaucoma,33,(9)
MLA：
Gao Xinbo,et al."Efficacy and Safety of Surgical Peripheral Iridectomy, Goniosynechialysis, and Goniotomy for Advanced Primary Angle-closure Glaucoma without Cataract: One-year Results of a Multicenter Study".Journal Of Glaucoma 33..9(2024):632-639

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