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Two-year outcomes of combined surgical peripheral iridectomy, goniosynechialysis, and goniotomy for advanced primary angle-closure glaucoma without cataract: A multicenter study

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Pubmed体系：
作者：
Lin Fengbin[1] * ; Li Liu[2] * ; Lu Ping[3] * ; Tang Li[4] ; Zhang Yao[4] ; Xie Lin[5] ; Zhu Xiaomin[5] ; Tang Guangxian[6] ; Zhang Hengli[6] ; Lu Lan[7] ; Xiao Meichun[7] ; Xu Jiangang[1] ; Song Yunhe[1] ; Peng Yuying[1] ; Li Xiaoyan[3] ; Chen Weirong[1] ; Zhou Fengqi[8] ; Wang Ningli[9] ; Barton Keith[10] ; Park Ki Ho[11] ; Aung Tin[12] ; Weinreb Robert N[13] ; Tham Clement C[14] ; Lam Dennis S C[15] ; Fan Sujie[3] ; Han Ying[16] ; Zhang Xiulan[1] ;
机构： [1]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China [2]Nanchang First Hospital (The Third Affiliated Hospital of Nanchang University), Nanchang, China [3]Handan City Eye Hospital (The Third Hospital of Handan), Handan, China [4]Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu, China [5]Department of Ophthalmology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China [6]Department of Ophthalmology, Shijiazhuang People’s Hospital, Shijiazhuang, China [7]Department of Ophthalmology, Fujian Medical University Union Hospital, Fuzhou, China [8]Mayo Clinic College of Medicine and Science, Rochester, MN, USA [9]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China [10]NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, UCL Institute of Ophthalmology, London, UK [11]Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea [12]Singapore Eye Research Institute, Singapore National Eye Center, Singapore [13]Hamilton Glaucoma Center, Viterbi Family Department of Ophthalmology, and Shiley Eye Institute, University of California San Diego, CA, USA [14]Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong SAR, China [15]The Primasia International Eye Research Institute of The Chinese University of Hong Kong (Shenzhen), Shenzhen, China [16]Department of Ophthalmology, University of California, San Francisco, CA, USA
出处：
DOI： 10.1016/j.apjo.2025.100166

关键词： Angle-closure glaucoma Surgical peripheral iridectomy Minimally invasive glaucoma surgery Goniosynechialysis Goniotomy

摘要：
To evaluate the two-year outcomes of combined surgical peripheral iridectomy (SPI), goniosynechialysis (GSL), and goniotomy (GT) for advanced primary angle-closure glaucoma (PACG) without cataract.Multicenter prospective study.The study included patients who received a combined SPI + GSL + GT for advanced PACG without cataract, all completed a 24-month follow-up. Outcome measures included changes in intraocular pressure (IOP), best-corrected visual acuity (BCVA), use of anti-glaucoma medications, surgical success, and postoperative complications over the 24-month period.A total of 63 eyes from 51 patients with advanced PACG were included in the study. Among these, 37 eyes (58.7 %) achieved complete success, and 55 eyes (87.3 %) achieved qualified success. The mean IOPs at baseline and after 24 months were 28.8 ± 7.51 mm Hg and 15.8 ± 4.40 mm Hg, respectively (P < 0.001). The average number of anti-glaucoma medications decreased from 1.9 ± 1.4-0.8 ± 1.2 over the 24-month period (P < 0.001). The overall BCVA was stable during the follow-up period (P = 0.225). The primary complications observed included IOP spike (n = 9), hyphema (n = 7), and shallow anterior chamber (n = 3), all of which occurred within the first month postoperatively. Regression analysis showed that older age was positively associated with both complete success [odds ratio (OR) = 1.05; P = 0.030] and qualified success (OR = 1.08; P = 0.024).SPI + GSL + GT demonstrated safety and effectiveness in treating advanced PACG without cataract over the 24-month study period. This combined surgical approach should be considered a viable alternative to trabeculectomy for these patients.Copyright © 2025 The Authors. Published by Elsevier Inc. All rights reserved.

基金：
This research was supported by the National Key Research and Development Program of China (grant number: 2022YFC2502800), the Science and Technology Program of Guangzhou, China (grant number: 2024A03J0250), National Natural Science Foundation of China (grant number: 82401251), the China Postdoctoral Science Foundation (grant number: 2023M744052), Medical application technology tracking project in Hebei Province (grant number: GZ2022094), Chongqing Natural Research Foundation (grant number: cstc2018jcyjAX0034), Chongqing Natural Research Foundation (grant number: CSTB2022NSCQ-MSX0077).
语种：
外文
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中科院(CAS)分区：
出版当年[2025]版：
大类 | 2 区 医学
小类 | 2 区 眼科学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 眼科学
第一作者：
第一作者机构： [1]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Lin Fengbin,Li Liu,Lu Ping,et al.Two-year outcomes of combined surgical peripheral iridectomy, goniosynechialysis, and goniotomy for advanced primary angle-closure glaucoma without cataract: A multicenter study[J].Asia-Pacific Journal Of Ophthalmology (Philadelphia, Pa.).2025,100166.doi:10.1016/j.apjo.2025.100166.
APA：
Lin Fengbin,Li Liu,Lu Ping,Tang Li,Zhang Yao...&Zhang Xiulan.(2025).Two-year outcomes of combined surgical peripheral iridectomy, goniosynechialysis, and goniotomy for advanced primary angle-closure glaucoma without cataract: A multicenter study.Asia-Pacific Journal Of Ophthalmology (Philadelphia, Pa.),,
MLA：
Lin Fengbin,et al."Two-year outcomes of combined surgical peripheral iridectomy, goniosynechialysis, and goniotomy for advanced primary angle-closure glaucoma without cataract: A multicenter study".Asia-Pacific Journal Of Ophthalmology (Philadelphia, Pa.) .(2025):100166

相关文献

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