机构：[1]Department of General Surgery, Shanghai Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.[2]Department of Hepatobiliary and Pancreatic (HBP) Surgery, Changhai Hospital, Naval Medical University, Shanghai, China.[3]Department of Hepatobiliary and Pancreatic (HBP) Surgery, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Pumilio RNA-binding family member 1 (PUM1) has been implicated in both the progression of colorectal cancer and the regulation of inflammation. The role of PUM1 in the polarization of tumor-associated macrophages (TAMs) into the M2 phenotype has not yet been reported in hepatocellular carcinoma. Using the PUM1-knockout mice model, flow cytometry, and IHC, we validated the role of PUM1 in hepatocellular carcinoma (HCC) TAMs. One-way analysis of variance (ANOVA) or student's t-tests was used to compare the experimental groups. We found that PUM1 inhibited anti-tumor immunity in HCC through TAM-mediated inhibition of CD8+ T cells. We also showed that PUM1 promotes the transformation of TAMs into pro-tumorigenic M2-like phenotypes by activating cAMP signaling pathway. This study emphasized the potential of PUM1 as a target for immunotherapy in HCC through TAMs. The present study revealed the molecular mechanism underlying the pro-tumor role of PUM1 in HCC.
第一作者机构：[1]Department of General Surgery, Shanghai Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
共同第一作者：
通讯作者：
通讯机构：[2]Department of Hepatobiliary and Pancreatic (HBP) Surgery, Changhai Hospital, Naval Medical University, Shanghai, China.[3]Department of Hepatobiliary and Pancreatic (HBP) Surgery, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.[*1]Department of Hepatobiliary and Pancreatic (HBP) Surgery, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, 1279 Sanmen Road, Hongkou District, Shanghai 200434, China[*2]Department of Hepatobiliary and Pancreatic (HBP) Surgery, Changhai Hospital, Navy Medical University, No. 168 Changhai Road, Yangpu District, Shanghai 200433, China
推荐引用方式(GB/T 7714)：
Yu Yang,Nie Gang,Ren Yi-Wei,et al.Pumilio RNA binding family member 1 deficiency activates anti-tumor immunity in hepatocellular carcinoma via restraining M2 macrophage polarization[J].CELL CYCLE.2024,23(6):682-692.doi:10.1080/15384101.2024.2355825.
APA：
Yu Yang,Nie Gang,Ren Yi-Wei,Ouyang Liu&Ni Chen-Ming.(2024).Pumilio RNA binding family member 1 deficiency activates anti-tumor immunity in hepatocellular carcinoma via restraining M2 macrophage polarization.CELL CYCLE,23,(6)
MLA：
Yu Yang,et al."Pumilio RNA binding family member 1 deficiency activates anti-tumor immunity in hepatocellular carcinoma via restraining M2 macrophage polarization".CELL CYCLE 23..6(2024):682-692
