The 3-hydroxyanthranilic acid (3-HAA), a derivative of kynurenine, was reported to suppress tumor growth. However, the function of 3-HAA largely remains unclear. Here, we report that 3-hydroxyanthranilic acid (3-HAA) is lower in tumor cells, while adding exogenous 3-HAA induces apoptosis in hepatocellular carcinoma by binding YY1. This 3-HAA binding of YY1 leads to phosphorylation of YY1 at the Thr 398 by PKC zeta, concomitantly enhances YY1 chromatin binding activity to increase expression of target genes. These findings demonstrate that 3-HAA is a ligand of YY1, suggesting it is a promising therapeutic candidate for HCC.
基金：
Ministry of Science and Technology of the People's Republic of ChinaMinistry of Science and Technology, China [2018YFC1313205]; Shanghai Committee of Science and TechnologyShanghai Science & Technology Committee [11DZ2260200, 20JC1410100]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81572300, 81872342, 91957120]
第一作者机构：[1]Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Chinese Minist Educ,Hongqiao Int Inst Med,Basic M, Shanghai, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Chinese Minist Educ,Hongqiao Int Inst Med,Basic M, Shanghai, Peoples R China[2]Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Dept Nucl Med, Shanghai, Peoples R China
推荐引用方式(GB/T 7714)：
Shi Zhaopeng,Gan Guifang,Xu Xiang,et al.Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1[J].JOURNAL OF HEMATOLOGY & ONCOLOGY.2021,14(1):doi:10.1186/s13045-021-01165-4.
APA：
Shi, Zhaopeng,Gan, Guifang,Xu, Xiang,Zhang, Jieying,Yuan, Yuan...&Mi, Jun.(2021).Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1.JOURNAL OF HEMATOLOGY & ONCOLOGY,14,(1)
MLA：
Shi, Zhaopeng,et al."Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1".JOURNAL OF HEMATOLOGY & ONCOLOGY 14..1(2021)
医学