机构：[1]Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, China.[2]Department of Epidemiology & Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China.[3]Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.[4]Department of Hematology, The Affiliated Hospital of Jining Medical University, Jining, Shandong, 272000, China.[5]Department of Hematology, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China.[6]Department of Hematology, Tai'an Central Hospital, Tai'an, Shandong, 271000, China.[7]Department of Hematology, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu, 222061, China.[8]Department of Hematology, The General Hospital of Wanbei Coal-Electric Group, Suzhou, Anhui, 234011, China.[9]Department of Hematology, Yancheng First People's Hospital, Yancheng, Jiangsu, 224001, China.[10]Department of Hematology, The First People's Hospital of Huai'an, Huai'an, Jiangsu, 223300, China.[11]Department of Pathology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, China.[12]Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100005, China.临床科室血液内科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[13]Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, 221006, China.[14]Key Laboratory of Bone Marrow Stem Cell, Xuzhou, Jiangsu, 221006, China.
Aim: This multicenter retrospective study aimed to develop a novel prognostic system for extranodal natural killer/T-cell lymphoma (ENKTL) patients in the era of pegaspargase/L-asparaginase. Materials & methods: A total of 844 newly diagnosed ENKTL patients were included. Results: Multivariable analysis confirmed that Eastern Cooperative Oncology Group performance status, lactate dehydrogenase, Chinese Southwest Oncology Group and Asia Lymphoma Study Group ENKTL (CA) system, and albumin were independent prognostic factors. By rounding up the hazard ratios from four significant variables, a maximum of 7 points were assigned. The model of Huaihai Lymphoma Working Group-Natural killer/T-cell Lymphoma prognostic index (NPI) was identified with four risk groups and the 5-year overall survival was 88.2, 66.7, 54.3 and 30.5%, respectively. Conclusion: Huaihai Lymphoma Working Group-NPI provides a feasible stratification system for patients with ENKTL in the era of pegaspargase/L-asparaginase.
基金：
Natural Science Foundation of Jiangsu Province, Grant/Award Number BK20171181; Jiangsu Key Research and Development Project of Social Development,Grant/Award Number BE2019638; and Young Medical Talents of Jiangsu Science and Education Health Project, Grant/Award Number QNRC2016791.
第一作者机构：[1]Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, China.[2]Department of Epidemiology & Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, China.[13]Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, 221006, China.[14]Key Laboratory of Bone Marrow Stem Cell, Xuzhou, Jiangsu, 221006, China.
推荐引用方式(GB/T 7714)：
Shen Ziyuan,Zhang Xudong,Li Yujie,et al.A novel prognostic index for extranodal natural killer/T-cell lymphoma in the era of pegaspargase/L-asparaginase[J].Future Oncology (London, England).2024,20(28):2071-2081.doi:10.1080/14796694.2024.2376512.
APA：
Shen Ziyuan,Zhang Xudong,Li Yujie,Chen Xicheng,Xing Xing...&Sang Wei.(2024).A novel prognostic index for extranodal natural killer/T-cell lymphoma in the era of pegaspargase/L-asparaginase.Future Oncology (London, England),20,(28)
MLA：
Shen Ziyuan,et al."A novel prognostic index for extranodal natural killer/T-cell lymphoma in the era of pegaspargase/L-asparaginase".Future Oncology (London, England) 20..28(2024):2071-2081
