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Prognostic factors for intermediate- or high-risk neuroblastomas in children in China

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机构： [1]Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, No 2, Xihuan South Road, Daxing Zone, Beijing, China

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关键词： Child Neuroblastoma Patients Risk Assessment Survival

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Evidence regarding the characteristics and prognosis of neuroblastoma (NBL) in China is limited. We aimed to investigate the characteristics and prognosis of intermediate- or high-risk NBL in children in China.We included 147 patients with intermediate- or high-risk NBL evaluated from January 2006 to March 2015. The patients were aged 1 month to 15.5 years, 66% of them were boys, and 117 (79.6%) were diagnosed with high-risk NBL.After a median follow-up of 32.5 months, 80 (45.6%) patients survived, with a median survival time of 48 months (95% confidence interval [CI]: 36.41-59.59). High-risk patients (hazard ratio [HR]: 12.467; 95% CI: 11.029-12.951), partial response (PR) (HR: 1.200; 95% CI: 1.475-2.509) or progression disease (PD) (HR: 1.924; 95% CI: 1.623-3.012) after induction chemotherapy, and intracranial metastasis (HR: 3.057; 95% CI: 0.941-4.892) were independent risk factors for survival (p < 0.05) and postrelapse survival (p < 0.05). NBL relapse, male sex, and PR or PD after induction chemotherapy were risk factors for event-free survival (p < 0.05).In addition to previously established independent risk factors, such as age, risk group, and relapse, efficacy of induction chemotherapy and intracranial metastasis play significant roles in the prognosis of NBL.© 2023. The Author(s).

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出版当年[2022]版：

大类 | 3 区医学

小类 | 3 区儿科

最新[2023]版：

大类 | 3 区医学

小类 | 3 区儿科

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出版当年[2021]版：

Q3 PEDIATRICS

最新[2023]版：

Q2 PEDIATRICS

影响因子： 2 最新[2023版] 2.4 最新五年平均 2.567 出版当年[2021版] 3.002 出版当年五年平均 2.125 出版前一年[2020版] 2.4 出版后一年[2022版]

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第一作者机构： [1]Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, No 2, Xihuan South Road, Daxing Zone, Beijing, China

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