机构：[1]Department of Ophthalmology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, [2]Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases/ Shanghai Clinical Research Center for Eye Diseases, Shanghai, China, [3]Department of Ophthalmology, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China, [4]Department of Ophthalmology, Shigatse People’s Hospital, Shigatse, Xizang, China, [5]High Altitude Ocular Disease Research Center of Shigatse People’s Hospital and Tongren Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
Background Mounting evidence suggests a correlation between heavy metals exposure and diabetes. Diabetic retinopathy (DR) is a prevalent and irreversible complication of diabetes that can result in blindness. However, studies focusing on the effects of exposure to heavy metals on DR remain scarce. Thus, this study aimed to investigate the potential correlation between heavy metals exposure and DR.Methods A total of 1,146 diabetics from the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2018 were included in this study. Heavy metal levels were measured via urine testing. Weighted logistic regression, Bayesian kernel machine regression (BKMR), weighted quantile sum (WQS) regression, and restricted cubic spline (RCS) were utilized to investigate the potential relationships between exposure to 10 heavy metals and DR. Finally, subgroup analysis was conducted based on the glycemic control status.Results Among the 1,146 participants, 239 (20.86%) were diagnosed with DR. Those with DR had worse glycemic control and a higher prevalence of chronic kidney disease compared to those without DR. Moreover, both the WQS regression and BKMR models demonstrated a positive relationship between exposure to mixed heavy metals and the risk of DR. The results of weighted logistic regression revealed a positive correlation between cobalt (Co) and antimony (Sb) exposure and the risk of DR (OR = 1.489, 95%CI: 1.064-2.082, p = 0.021; OR = 1.475, 95% CI: 1.084-2.008, p = 0.014), while mercury (Hg) exposure was found to promote DR exclusively in the group with good glycemic control (OR = 1.509, 95% CI: 1.157-1.967, p = 0.003). These findings were corroborated by the results of the RCS analysis.Conclusion Heavy metal exposure is associated with an increased risk of DR, especially Sb, Co, and Hg exposure. Nevertheless, well-designed prospective studies are warranted to validate these findings.
基金：
National Natural Science Foundation of China [82371072]
第一作者机构：[1]Department of Ophthalmology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, [2]Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases/ Shanghai Clinical Research Center for Eye Diseases, Shanghai, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Ophthalmology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, [2]Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases/ Shanghai Clinical Research Center for Eye Diseases, Shanghai, China, [4]Department of Ophthalmology, Shigatse People’s Hospital, Shigatse, Xizang, China, [5]High Altitude Ocular Disease Research Center of Shigatse People’s Hospital and Tongren Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
推荐引用方式(GB/T 7714)：
Meng Chunren,Gu Chufeng,Cai Chunyang,et al.Associations of heavy metal exposure with diabetic retinopathy in the US diabetic population: a cross-sectional study[J].FRONTIERS IN PUBLIC HEALTH.2024,12:doi:10.3389/fpubh.2024.1401034.
APA：
Meng, Chunren,Gu, Chufeng,Cai, Chunyang,He, Shuai,Lai, Dongwei&Qiu, Qinghua.(2024).Associations of heavy metal exposure with diabetic retinopathy in the US diabetic population: a cross-sectional study.FRONTIERS IN PUBLIC HEALTH,12,
MLA：
Meng, Chunren,et al."Associations of heavy metal exposure with diabetic retinopathy in the US diabetic population: a cross-sectional study".FRONTIERS IN PUBLIC HEALTH 12.(2024)
