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Brain-wide functional connectivity alterations and their cognitive correlates in subjective cognitive decline

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机构: [1]Nanjing Med Univ, Dept Rehabil, Affiliated Brain Hosp, Nanjing, Peoples R China [2]Nanjing Med Univ, Clin Coll 4, Nanjing, Peoples R China [3]Southeast Univ, Nanjing Tongren Hosp, Sch Med, Dept Radiol, Nanjing, Peoples R China [4]Nanjing Med Univ, Dept Neurosurg, Affiliated Brain Hosp, Nanjing, Jiangsu, Peoples R China [5]Univ Cape Town, Fac Hlth Sci, Dept Human Biol, Cape Town, South Africa [6]Yangzhou Univ, Northern Jiangsu Peoples Hosp, Dept Neurol, Clin Med Coll, Yangzhou, Peoples R China [7]Nanjing Univ, Nanjing Drum Tower Hosp, Affiliated Hosp, Dept Radiol,Med Sch, Nanjing, Peoples R China [8]Nanjing Univ, Inst Med Imaging & Artificial Intelligence, Nanjing, Peoples R China [9]Nanjing Univ, Affiliated Drum Tower Hosp, Med Imaging Ctr, Med Sch, Nanjing, Peoples R China
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关键词: subjective cognitive decline functional connectivity Alzheimer's disease brain-wide association study (BWAS) fMRI

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Background: Individuals with subjective cognitive decline (SCD) are at risk of developing Alzheimer's Disease (AD). Traditional seed-based analysis has shown biased functional connectivity (FC) in SCD individuals. To investigate unbiased altered FC by the brain-wide association study (BWAS) and to determine its association with cognition in SCD individuals. Methods: Measure of association (MA) analysis was applied to detect significant voxels with FC changes. Based on these changes, we identified regions of interest (ROIs) and conducted ROI-wise FC analyses. Correlation analyses were then performed between these FC circuits and cognition. Results: MA analysis identified 10 ROIs with significantly altered voxels. ROI-wise FC analyses revealed 14 strengthened FC, predominantly parietal-occipital link alterations. The FC between the right superior occipital gyrus and the right postcentral gyrus correlated positively with executive function, while the FC between the right middle occipital gyrus and the left angular gyrus correlated positively with episodic memory in SCD individuals. Conclusion: SCD involves multifocal impairments, of which regions of default mode network (DMN) and occipital lobe should be specially focused. Cross-hemispheric alterations indicate an internal interactive impairment pattern in SCD. The reduced FC between the right superior occipital gyrus and the right postcentral gyrus, and between the right middle occipital gyrus and the left angular gyrus, which correlate with specific cognitive functions, could serve as potential biomarkers for SCD diagnosis.

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出版当年[2023]版:
大类 | 3 区 医学
小类 | 3 区 神经科学
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大类 | 3 区 医学
小类 | 3 区 神经科学
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Q2 NEUROSCIENCES
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第一作者机构: [1]Nanjing Med Univ, Dept Rehabil, Affiliated Brain Hosp, Nanjing, Peoples R China
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通讯机构: [7]Nanjing Univ, Nanjing Drum Tower Hosp, Affiliated Hosp, Dept Radiol,Med Sch, Nanjing, Peoples R China [8]Nanjing Univ, Inst Med Imaging & Artificial Intelligence, Nanjing, Peoples R China [9]Nanjing Univ, Affiliated Drum Tower Hosp, Med Imaging Ctr, Med Sch, Nanjing, Peoples R China
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