Background: Individuals with subjective cognitive decline (SCD) are at risk of developing Alzheimer's Disease (AD). Traditional seed-based analysis has shown biased functional connectivity (FC) in SCD individuals. To investigate unbiased altered FC by the brain-wide association study (BWAS) and to determine its association with cognition in SCD individuals. Methods: Measure of association (MA) analysis was applied to detect significant voxels with FC changes. Based on these changes, we identified regions of interest (ROIs) and conducted ROI-wise FC analyses. Correlation analyses were then performed between these FC circuits and cognition. Results: MA analysis identified 10 ROIs with significantly altered voxels. ROI-wise FC analyses revealed 14 strengthened FC, predominantly parietal-occipital link alterations. The FC between the right superior occipital gyrus and the right postcentral gyrus correlated positively with executive function, while the FC between the right middle occipital gyrus and the left angular gyrus correlated positively with episodic memory in SCD individuals. Conclusion: SCD involves multifocal impairments, of which regions of default mode network (DMN) and occipital lobe should be specially focused. Cross-hemispheric alterations indicate an internal interactive impairment pattern in SCD. The reduced FC between the right superior occipital gyrus and the right postcentral gyrus, and between the right middle occipital gyrus and the left angular gyrus, which correlate with specific cognitive functions, could serve as potential biomarkers for SCD diagnosis.
基金:
National Natural Science Foundation of China [81701675, 2023-LCYJ-MS-11]; Special Funded Project of Nanjing Drum Tower Hospital [RC2022-023]; Development Plan (Social Development) Project of Jiangsu Province [BE2018608, BE2022679]; Medical Research Program of Jiangsu Health Commission [M2022059]
第一作者机构:[1]Nanjing Med Univ, Dept Rehabil, Affiliated Brain Hosp, Nanjing, Peoples R China
共同第一作者:
通讯作者:
通讯机构:[7]Nanjing Univ, Nanjing Drum Tower Hosp, Affiliated Hosp, Dept Radiol,Med Sch, Nanjing, Peoples R China[8]Nanjing Univ, Inst Med Imaging & Artificial Intelligence, Nanjing, Peoples R China[9]Nanjing Univ, Affiliated Drum Tower Hosp, Med Imaging Ctr, Med Sch, Nanjing, Peoples R China
推荐引用方式(GB/T 7714):
Huang Shaochun,Wang Siyu,Che Zigang,et al.Brain-wide functional connectivity alterations and their cognitive correlates in subjective cognitive decline[J].FRONTIERS IN NEUROSCIENCE.2024,18:doi:10.3389/fnins.2024.1438260.
APA:
Huang, Shaochun,Wang, Siyu,Che, Zigang,Ge, Honglin,Yan, Zheng...&Chen, Jiu.(2024).Brain-wide functional connectivity alterations and their cognitive correlates in subjective cognitive decline.FRONTIERS IN NEUROSCIENCE,18,
MLA:
Huang, Shaochun,et al."Brain-wide functional connectivity alterations and their cognitive correlates in subjective cognitive decline".FRONTIERS IN NEUROSCIENCE 18.(2024)