机构：[1]Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.[2]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.[3]School of Ophthalmology and Optometry and School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, China.[4]Duke-NUS Medical School, Singapore.[5]Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore.[6]Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, United States.[7]Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, Georgia, United States.[8]Emory Empathetic AI for Health Institute, Emory University, Atlanta, Georgia, United States.
The purpose of this study was to investigate the effect of globe and optic nerve (ON) morphologies and tissue stiffnesses on gaze-induced optic nerve head deformations using parametric finite element modeling and a design of experiment (DOE) approach.A custom software was developed to generate finite element models of the eye using 10 morphological parameters: dural radius, scleral, choroidal, retinal, pial and peripapillary border tissue thicknesses, prelaminar tissue depth, lamina cribrosa (LC) depth, ON radius, and ON tortuosity. A central composite face-centered design (1045 models) was used to predict the effects of each morphological factor and their interactions on LC strains induced by 13 degrees of adduction. Subsequently, a further DOE analysis (1045 models) was conducted to study the effects and potential interactions between the top five morphological parameters identified from the initial DOE study and five critical tissue stiffnesses.In the DOE analysis of 10 morphological parameters, the 5 most significant factors were ON tortuosity, dural radius, ON radius, scleral thickness, and LC depth. Further DOE analysis incorporating biomechanical parameters highlighted the importance of dural and LC stiffness. A larger dural radius and stiffer dura increased LC strains but the other main factors had the opposite effects. Notably, the significant interactions were found between dural radius with dural stiffness, ON radius, and ON tortuosity.This study highlights the significant impact of morphological factors on LC deformations during eye movements, with key morphological effects being more pronounced than tissue stiffnesses.
基金：
National Natural Science Foundation of China (12272030, 12002025);National Glaucoma Research, a program of the Bright Focus Foundation,for support of this research (G2021010S [M.G.])
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|2 区医学
小类|2 区眼科学
最新[2023]版：
大类|2 区医学
小类|2 区眼科学
第一作者：
第一作者机构：[1]Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
通讯作者：
通讯机构：[1]Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.[2]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.[3]School of Ophthalmology and Optometry and School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, China.[4]Duke-NUS Medical School, Singapore.[5]Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore.[6]Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, United States.[7]Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, Georgia, United States.[8]Emory Empathetic AI for Health Institute, Emory University, Atlanta, Georgia, United States.
推荐引用方式(GB/T 7714)：
Liu Tingting,Hung Pham Tan,Wang Xiaofei,et al.Effect of Eye Globe and Optic Nerve Morphologies on Gaze-Induced Optic Nerve Head Deformations[J].Investigative Ophthalmology & Visual Science.2024,65(8):48.doi:10.1167/iovs.65.8.48.
APA：
Liu Tingting,Hung Pham Tan,Wang Xiaofei&Girard Michaël J A.(2024).Effect of Eye Globe and Optic Nerve Morphologies on Gaze-Induced Optic Nerve Head Deformations.Investigative Ophthalmology & Visual Science,65,(8)
MLA：
Liu Tingting,et al."Effect of Eye Globe and Optic Nerve Morphologies on Gaze-Induced Optic Nerve Head Deformations".Investigative Ophthalmology & Visual Science 65..8(2024):48
