机构：[1]Ophthalmic Engineering and Innovation Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore[2]Singapore Eye Research Institute, Singapore National Eye Center, Singapore[3]Duke-NUS, Singapore[4]Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University, Heidelberg, Germany[5]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, and Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing, China研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院
PURPOSE. To use finite element (FE) analysis to predict the optic nerve sheath traction forces that act on the optic nerve head (ONH) following horizontal eye movements, and the resulting stress levels in the peripapillary connective tissues of the ONH (Bruch's membrane [BM] and sclera). METHODS. An FE model of a healthy eye was reconstructed in primary gaze position that included details from the orbital and ONH tissues. Optic nerve sheath traction forces and peripapillary tissue stresses in both adduction and abduction (138) were computed using FE analysis. RESULTS. Our models predicted that, following eye movements, the ONH was sheared in the transverse plane due to the pulling action of the optic nerve. The optic nerve sheath traction forces were 90 mN in abduction and 150 mN in adduction. Peripapillary tissue stresses were concentrated in the nasal and temporal quadrants. In adduction, scleral stresses were highest in the temporal region, and BM stresses were slightly higher in the nasal region. This trend was reversed in abduction. CONCLUSIONS. Following eye movements, our models predicted high optic nerve sheath traction forces of the same order of magnitude as extraocular muscle forces. Optic nerve traction resulted in significant peripapillary stresses, and thus may have a role to play in the development of peripapillary zones, glaucoma, and myopia.
基金：
Singapore Eye Research Institute Pilot Grant
(R1228/34/2015), from the Ministry of Education, Academic
Research Funds, Tier 1 (R-397-000-181-112) and from a National
University of Singapore Young Investigator Award (NUSYIA_
FY13_P03, R-397-000-174-133).
第一作者机构：[1]Ophthalmic Engineering and Innovation Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore
通讯作者：
通讯机构：[1]Ophthalmic Engineering and Innovation Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore[2]Singapore Eye Research Institute, Singapore National Eye Center, Singapore[*1]Ophthalmic Engineering and Innovation Laboratory, Department of Biomedical Engineering, National University of Singapore, Engineering Block 4, #04-8, 4 Engineering Drive 3, 117583 Singapore
推荐引用方式(GB/T 7714)：
Wang Xiaofei,Fisher Liam K.,Milea Dan,et al.Predictions of Optic Nerve Traction Forces and Peripapillary Tissue Stresses Following Horizontal Eye Movements[J].INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.2017,58(4):2044-2053.doi:10.1167/iovs.16-21319.
APA：
Wang, Xiaofei,Fisher, Liam K.,Milea, Dan,Jonas, Jost B.&Girard, Michael J. A..(2017).Predictions of Optic Nerve Traction Forces and Peripapillary Tissue Stresses Following Horizontal Eye Movements.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,58,(4)
MLA：
Wang, Xiaofei,et al."Predictions of Optic Nerve Traction Forces and Peripapillary Tissue Stresses Following Horizontal Eye Movements".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 58..4(2017):2044-2053
医学