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Size and Shape of Bruch's Membrane Opening in Relationship to Axial Length, Gamma Zone, and Macular Bruch's Membrane Defects

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机构: [1]Capital Med Univ, Beijing Ophthalmol & Visual Sci Key Lab, Beijing Inst Ophthalmol, Beijing Tongren Hosp, Beijing, Peoples R China [2]Capital Med Univ, Beijing Key Lab Intraocular Tumor Diag & Treatmen, Beijing Ophthalmol & Visual Sci Key Lab, Beijing Tongren Eye Ctr,Beijing Tongren Hosp, Beijing, Peoples R China [3]Ruprecht Karis Univ, Med Fac Mannheim, Dept Ophthalmol, Mannheim, Germany
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关键词: Bruch's membrane opening axial length myopia parapapillary gamma zone macular Bruch's membrane defects optical coherence tomography optic nerve head Beijing Eye Study

摘要:
PURPOSE. To assess axial elongation-associated characteristics in Bruch's membrane opening (BMO) as the inner optic nerve head lamella. METHODS. Participants of the population-based Beijing Eye Study without glaucoma underwent optical coherence tomography for measurement of the BMO size and shape. RESULTS. The study included 365 individuals (mean age, 61.0 +/- 8.7 years; range, 50-88 years; axial length, 24.45 +/- 1.99 mm; range, 21.32-30.88 mm). Larger horizontal (mean: 1.62 +/- 0.28 mm) and vertical (mean: 1.74 +/- 0.27 mm) BMO diameters were linearly associated with longer axial length beyond an axial length of 26.0 mm (horizontal diameter: P < 0.001; standardized regression coefficient beta: 0.66; nonstandardized regression coefficient B: 0.22; 95% confidence interval (CI): 0.16, 0.27; vertical diameter: P < 0.001; beta: 40; B: 0.12; 95% CI: 0.06, 0.18). In multivariable analysis, wider largest gamma zone was associated with larger intrapapillary Bruch's membrane (BM) overhanging on the side opposite to the largest gamma zone (P = 0.006; beta: 0.14; B: 0.35; 95% CI: 0.10, 0.60) and with longer horizontal BMO diameter (P < 0.001; beta: 0.46; B: 0.59; 95% CI: 0.46, 0.73). The widest BM overhanging location (superior to nasal) was inversely correlated with the widest gamma zone location (inferior to temporal). Within the axial length group of >= 28.0 mm, eyes with macular BM defects had a less markedly increased BMO than those without macular BM defects (2.27 +/- 0.18 vs. 2.71 +/- 0.41 mm; P = 0.019). The difference between horizontal BMO diameter minus horizontal gamma zone width decreased (P < 0.001) with longer axial length. CONCLUSIONS. Beyond 26.0 mm of axial length, horizontal and vertical BMO diameter increased by 0.21 mm (95% CI: 0.16, 0.27) and 0.12 mm (95% CI: 0.06, 0.18), respectively, for each millimeter of axial elongation. Gamma zone may develop due to an axial elongation-associated BMO enlargement (beta: 0.46) and, to a minor degree, a BMO shift in direction to the macula (b: 0.14). A large gamma zone may be protective against myopic macular BM defects.

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出版当年[2018]版:
大类 | 3 区 医学
小类 | 2 区 眼科学
最新[2023]版:
大类 | 2 区 医学
小类 | 2 区 眼科学
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出版当年[2017]版:
Q1 OPHTHALMOLOGY
最新[2023]版:
Q1 OPHTHALMOLOGY

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第一作者机构: [1]Capital Med Univ, Beijing Ophthalmol & Visual Sci Key Lab, Beijing Inst Ophthalmol, Beijing Tongren Hosp, Beijing, Peoples R China
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通讯机构: [1]Capital Med Univ, Beijing Ophthalmol & Visual Sci Key Lab, Beijing Inst Ophthalmol, Beijing Tongren Hosp, Beijing, Peoples R China [*1]Beijing Inst Ophthalmol, 17 Hougou Lane, Beijing 100005, Peoples R China
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