PURPOSE. To assess prevalence and size of the parapapillary beta zone and gamma zone in a healthy population. METHODS. Within the population-based Beijing Eye Study, individuals without retinal or optic nerve disease were selected. Using optical coherence tomography (OCT), we measured the parapapillary beta zone (defined by presence of Bruch's membrane and absence of RPE) and gamma zone (region between Bruch's membrane end and optic disc border). RESULTS. The study included 723 individuals (mean age: 59.5 +/- 7.6 years; range: 50-90 years). The beta zone was detected in 525 eyes (72.6%; 95% confidence interval [CI]: 69.4, 75.9). A larger maximum width of the beta zone (mean: 253 +/- 225 mu m) was associated (multivariate analysis; regression coefficient r(2) : 0.36) with older age (P < 0.001; standardized regression coefficient beta: 0.28), thinner temporal parapapillary choroidal thickness (P < 0.001; beta: -0.21), longer axial length (P < 0.001; beta: 0.14), longer vertical Bruch's membrane opening (BMO) length (P < 0.001; beta: 0.32), shorter horizontal BMO length (P = 0.003; beta: -0.12), and more pronounced vertical optic disc rotation of (P < 0.001; beta: 0.15). The gamma zone was detected in 190 eyes (26.3 +/- 1.6%; 95% CI: 23.1, 29.5). A larger maximal width of the gamma zone (mean: 86 +/- 187 mu m) was (r(2) : 0.49) associated with longer axial length (P < 0.001; beta: 0.46), thinner central corneal thickness (P < 0.001; beta: 0.10), thinner temporal parapapillary choroidal thickness (P < 0.001; beta: -0.11), longer vertical (P < 0.001; beta: 0.15), and horizontal (P = 0.02; beta: 0.08) BMO length, and more pronounced vertical rotation of optic disc (P < 0.001; beta: 0.32). CONCLUSIONS. As measured by OCT in this healthy adult Chinese population, the gamma zone was mainly associated with longer axial length but not with age, while the beta zone was correlated mainly with older age and also with axial length. Both zones were largest in the temporal parapapillary region and smallest in the nasal region.
基金：
Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (Beijing, China) [ZYLX201307]; National Natural Science Foundation of China (Beijing, China)National Natural Science Foundation of China (NSFC) [81272981]; Beijing Natural Science Foundation (Beijing, China)Beijing Natural Science Foundation [7151003]; Advanced Health Care Professionals Development Project of Beijing Municipal Health Bureau (Beijing, China) [2014-2-003]
第一作者机构：[1]Capital Med Univ, Beijing Tongren Eye Ctr, Beijing Tongren Hosp, Beijing Ophthalmol & Visual Sci Key Lab,Beijing K, Beijing, Peoples R China[2]Capital Med Univ, Beijing Ophthalmol & Visual Sci Key Lab, Beijing Tongren Hosp, Beijing Inst Ophthalmol, Beijing, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tongren Eye Ctr, Beijing Tongren Hosp, Beijing Ophthalmol & Visual Sci Key Lab,Beijing K, Beijing, Peoples R China[2]Capital Med Univ, Beijing Ophthalmol & Visual Sci Key Lab, Beijing Tongren Hosp, Beijing Inst Ophthalmol, Beijing, Peoples R China[*1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Dong Cheng District, Beijing 100730, China[*2]Beijing Institute of Ophthalmology, 17 Hougou Lane, Chong Wen Men, Beijing 100005, China[*3]Beijing Institute of Ophthalmology, 17 Hougou Lane, Chong Wen Men, Beijing 100005, China
推荐引用方式(GB/T 7714)：
Zhang Qi,Wang Ya Xing,Wei Wen Bin,et al.Parapapillary Beta Zone and Gamma Zone in a Healthy Population: The Beijing Eye Study 2011[J].INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.2018,59(8):3320-3329.doi:10.1167/iovs.18-24141.
APA：
Zhang, Qi,Wang, Ya Xing,Wei, Wen Bin,Xu, Liang&Jonas, Jost B..(2018).Parapapillary Beta Zone and Gamma Zone in a Healthy Population: The Beijing Eye Study 2011.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,59,(8)
MLA：
Zhang, Qi,et al."Parapapillary Beta Zone and Gamma Zone in a Healthy Population: The Beijing Eye Study 2011".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 59..8(2018):3320-3329
医学