机构：[1]Ophthalmic Engineering & Innovation Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore[2]Translational Ophthalmic Pathology, Singapore Eye Research Institute, Ophthalmic Pathology Service, Singapore National Eye Centre, Singapore[3]Duke-National University of Singapore Medical School, Singapore[4]Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University, Heidelberg, Germany[5]Beijing Institute of Ophthalmology, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, and Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing, China研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院
PURPOSE. The purpose of this study was to measure the rupture pressure and the biomechanical properties of porcine Bruch's membrane (BM)-choroid complex (BMCC) and the influences of BM on optic nerve head (ONH) tissues. METHODS. The biomechanical properties of BMCC were extracted through uniaxial tensile tests of 10 BMCC specimens from 10 porcine eyes; the rupture pressures of BMCC were measured through burst tests of 20 porcine eyes; and the influence of BM on IOP-induced ONII deformations were investigated using finite element (FE) analysis. RESULTS. Uniaxial experimental results showed that the average elastic (tangent) moduli of BMCC samples at 0% and 5% strain were 1.60 +/- 0.81 and 2.44 +/- 1.02 MPa, respectively. Burst tests showed that, on average, BMCC could sustain an IOP of 82 mm Hg before rupture. FE simulation results predicted that, under elevated IOP, prelamina tissue strains increased with increasing BM stiffness. On the contrary, lamina cribrosa strains showed an opposite trend but the effects were small. CONCLUSIONS. BMCC stiffness is comparable or higher than those of other ocular tissues and can sustain a relatively high pressure before rupture. Additionally, BM may have a nonnegligible influence on IOP-induced ONH deformations.
基金：
National University of SingaporeNational University of Singapore [NUSYIA FY13 P03, R-397-000-174-133]; Ministry of Education, SingaporeMinistry of Education, Singapore [R-397-000-280-112]
第一作者机构：[1]Ophthalmic Engineering & Innovation Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore
通讯作者：
通讯机构：[1]Ophthalmic Engineering & Innovation Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore[2]Translational Ophthalmic Pathology, Singapore Eye Research Institute, Ophthalmic Pathology Service, Singapore National Eye Centre, Singapore[*1]Ophthalmic Engineering & Innovation Laboratory, Department of Biomedical Engineering, National University of Singapore, Engineering Block 4, #04-8, 4 Engineering Drive 3, Singapore 117583
推荐引用方式(GB/T 7714)：
Wang Xiaofei,Teoh Clarence Ken Guan,Chan Anita S. Y.,et al.Biomechanical Properties of Bruch's Membrane-Choroid Complex and Their Influence on Optic Nerve Head Biomechanics[J].INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.2018,59(7):2808-2817.doi:10.1167/iovs.17-22069.
APA：
Wang, Xiaofei,Teoh, Clarence Ken Guan,Chan, Anita S. Y.,Thangarajoo, Sathiyan,Jonas, Jost B.&Girard, Michael J. A..(2018).Biomechanical Properties of Bruch's Membrane-Choroid Complex and Their Influence on Optic Nerve Head Biomechanics.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,59,(7)
MLA：
Wang, Xiaofei,et al."Biomechanical Properties of Bruch's Membrane-Choroid Complex and Their Influence on Optic Nerve Head Biomechanics".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 59..7(2018):2808-2817
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