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Hyperbaric oxygen therapy alleviates intestinal dysfunction following traumatic brain injury via m6A regulation

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收录情况： ◇ SCIE

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机构： [1]Department of Hyperbaric Oxygen, The Fourth Affiliated Hospital of Nanjing Medical University, 210031 Nanjing, China. [2]Department of Neurosurgery, The Fourth Affiliated Hospital of Nanjing Medical University, 210031 Nanjing, China. [3]Department of Pathology, The Fourth Affiliated Hospital of Nanjing Medical University, 210031 Nanjing, China. [4]Department of Intensive Care Unit, Nanjing Tongren Hospital, School of Medicine, Southeast University, 211102 Nanjing, China. [5]College of Animal Science and Technology, Nanjing Agricultural University, 210095 Nanjing, China.

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关键词： hyperbaric oxygen therapy traumatic brain injury intestinal dysfunction m6A

摘要：

Hyperbaric oxygen (HBO) therapy can attenuate neurological impairment after traumatic brain injury (TBI) and alleviate intestinal dysfunction. However, the role and mechanism of HBO therapy in intestinal dysfunction following TBI remain unclear. Herein, by establishing a mouse model of controlled cortical impact (CCI), we found that HBO therapy reduced histopathological lesions and decreased the levels of inflammatory and oedema proteins in the intestinal tissues of mice 10 days after TBI. We also showed that HBO therapy improved microbiome abundance and probiotic (particularly g_Bifidobacterium) colonisation in mice post-CCI. Then, we identified that the m6A level imcreased notably in injured cortical tissue of CCI+HBO group compared with the CCI group following CCI. Thus, our results suggested that HBO therapy could alleviate TBI-induced intestinal dysfunction and m6A might participate in this regulation process, which provides new insights for exploring the specific mechanism and targets of HBO in the treatment of intestinal dysfunction after TBI, thereby improving the therapeutic effect of HBO.© The author(s).

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出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区医学：内科

最新[2023]版：

大类 | 3 区医学

小类 | 3 区医学：内科

JCR分区：

出版当年[2022]版：

Q2 MEDICINE, GENERAL & INTERNAL

最新[2023]版：

Q1 MEDICINE, GENERAL & INTERNAL

影响因子： 3.2 最新[2023版] 3.4 最新五年平均 3.6 出版当年[2022版] 3.6 出版当年五年平均 3.642 出版前一年[2021版] 3.2 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Hyperbaric Oxygen, The Fourth Affiliated Hospital of Nanjing Medical University, 210031 Nanjing, China.

共同第一作者：

通讯作者：

通讯机构： [2]Department of Neurosurgery, The Fourth Affiliated Hospital of Nanjing Medical University, 210031 Nanjing, China. [4]Department of Intensive Care Unit, Nanjing Tongren Hospital, School of Medicine, Southeast University, 211102 Nanjing, China. [5]College of Animal Science and Technology, Nanjing Agricultural University, 210095 Nanjing, China. [*1]Department of Intensive Care Unit, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, China [*2]College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China [*3]Department of Neurosurgery, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, China

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Hyperbaric oxygen therapy alleviates intestinal dysfunction following traumatic brain injury via m6A regulation

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